Palmatine from Mahonia bealei attenuates gut tumorigenesis in ApcMin/+ mice via inhibition of inflammatory cytokines

Autor: Xin He, Chun‑Hao Yu, Chun-Feng Zhang, Hui Li, Chang‑Run Guo, Cui‑Lan Dong, Wei‑Kun Ma, Chun-Su Yuan, Chong-Zhi Wang
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
Cancer Research
Mahonia bealei
medicine.medical_treatment
Berberine Alkaloids
Pharmacology
Biochemistry
Mice
chemistry.chemical_compound
0302 clinical medicine
cytokine
Medicine
Gastrointestinal Neoplasms
Mice
Knockout
biology
Interleukin
Palmatine
Articles
ApcMin/+ mice
Tumor Burden
medicine.anatomical_structure
Cytokine
Oncology
030220 oncology & carcinogenesis
Cytokines
Molecular Medicine
Inflammation Mediators
Adenomatous Polyposis Coli Protein
Mahonia
colorectal cancer
Proinflammatory cytokine
03 medical and health sciences
Cell Line
Tumor
palmatine
Genetics
Animals
Molecular Biology
Cell Proliferation
colon
Plant Extracts
business.industry
biology.organism_classification
Xenograft Model Antitumor Assays
Molecular medicine
Small intestine
Disease Models
Animal
030104 developmental biology
chemistry
inflammation
Apoptosis
Immunology
business
small intestine
Zdroj: Molecular Medicine Reports
ISSN: 1791-3004
1791-2997
DOI: 10.3892/mmr.2016.5285
Popis: Mahonia bealei is a Chinese folk medicine used to treat various ailments, in particular gastrointestinal inflammation-related illnesses, and palmatine is one of its active constituents. In this study, ApcMin/+ mice, a genetically engineered model, were used to investigate the effects of palmatine on the initiation and progression of gut inflammation and tumorigenesis enhanced by a high-fat diet. The in vitro antiproliferation and anti-inflammation effects of palmatine were evaluated on HT-29 and SW-480 human colorectal cancer cell lines. The concentration-related antiproliferative effects of palmatine on both cell lines (P
Databáze: OpenAIRE
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