Anti-inflammatory activity of Dalbergia sissoo leaves
| Autor: | S.W Hajare, J Sharma, A G Telang, Surendra K. Tandan, Sadanandavalli Retnaswami Chandra, J Lal |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Nystatin medicine.drug_class Vascular permeability Pharmacology Carrageenan Anti-inflammatory Capillary Permeability Mice chemistry.chemical_compound Oral administration Drug Discovery Botany Gastric mucosa medicine Animals Edema Rats Wistar Rosales Kaolin Plants Medicinal Dose-Response Relationship Drug biology Plant Extracts Anti-Inflammatory Agents Non-Steroidal Dalbergia sissoo General Medicine biology.organism_classification Acute toxicity Rats Plant Leaves medicine.anatomical_structure chemistry Gastric Mucosa Toxicity Female |
| Zdroj: | Fitoterapia. 72:131-139 |
| ISSN: | 0367-326X |
| DOI: | 10.1016/s0367-326x(00)00272-0 |
| Popis: | The possible anti-inflammatory activity of the 90% ethanolic extract of Dalbergia sissoo leaves (DSELE) was studied in different models of inflammation in rats after oral administration at doses of 100, 300 and 1000 mg/kg. DSELE significantly inhibited carrageenin, kaolin and nystatin-induced paw oedema, as well as the weight of granuloma induced by a cotton pellet. It also inhibited dye leakage in acetic acid-induced vascular permeability test in mice. DSELE was devoid of ulcerogenic effect on the gastric mucosa of rats in acute and chronic tests. In acute toxicity studies, it was found to be safe up to 10.125 g/kg, p.o. in the rat. It was concluded that the D. sissoo leaf extract possessed significant anti-inflammatory activity (in acute, sub-acute and chronic models of inflammation) without any side effect on gastric mucosa. |
| Databáze: | OpenAIRE |
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