Spinal cord transection modifies ileal fluid and electrolyte transport in rats
| Autor: | F.H. Rola, R.C. Palheta, Francisco de Assis Aquino Gondim, José Ronaldo Vasconcelos da Graça, Dário Augusto Ferreira de Queiroz, Aldo Ângelo Moreira Lima, Armênio Aguiar dos Santos, Camila L. Santos, B. A. Medeiros |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Central nervous system Motility Ileum Lesion Cellular and Molecular Neuroscience Electrolytes Internal medicine medicine Animals Rats Wistar Spinal cord injury Spinal Cord Injuries Analysis of Variance Endocrine and Autonomic Systems Chemistry Water Biological Transport medicine.disease Spinal cord Small intestine Rats Autonomic nervous system surgical procedures operative medicine.anatomical_structure Endocrinology Anesthesia Neurology (clinical) medicine.symptom human activities |
| Zdroj: | Autonomic neuroscience : basicclinical. 139(1-2) |
| ISSN: | 1566-0702 |
| Popis: | Spinal cord injury (SCI) is associated with severe autonomic changes, including inhibition of gastrointestinal (GI) motility. GI motility changes are known to affect electrolytes transport and these changes have not been adequately studied after SCI. We studied the ileal permeability to fluid and electrolytes in rats submitted to experimental spinal cord transection (SCT), between T4 and T5, throughout the first week after SCT. SCT increased ileal secretion of Na+ (P0.05) and decreased the Cl(-) absorption during the first week post SCI (P0.05). Water transport was also significantly altered, leading to increased water secretion following the Na+ gradient. Ileal secretion of K+ was significantly increased 1 and 7 days after spinal cord injury. To our knowledge, the present findings are the first direct evidence that SCT alters ileal electrolyte transport in rats. Further studies are necessary to evaluate the mechanisms involved in this phenomenon. |
| Databáze: | OpenAIRE |
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