Hatched 'egg' of thymoma with sarcoidosis
| Autor: | Kohei Aoki, Yoshiaki Inoue, Masatoshi Yamaguchi, Mitsuo Nakayama, Morihiro Higashi, Hiroki Fukuda, Masatoshi Gika, Ato Sugiyama, Tai Hato |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pathology
medicine.medical_specialty Thymoma Sarcoidosis lcsh:Surgery Mediastinal tumor Case Report Mediastinal Neoplasms lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Dystrophic calcification medicine Humans Aged Lung business.industry Calcinosis Nodule (medicine) Histology Thymus Neoplasms lcsh:RD1-811 Prognosis medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.anatomical_structure Oncology Round-shaped calcification 030220 oncology & carcinogenesis Rim calcification Female 030211 gastroenterology & hepatology Surgery medicine.symptom business Eggshell calcification Calcification |
| Zdroj: | World Journal of Surgical Oncology, Vol 17, Iss 1, Pp 1-4 (2019) World Journal of Surgical Oncology |
| ISSN: | 1477-7819 |
| Popis: | Background While calcification of thymoma is common, “eggshell” calcification is rare. We report a case of an eggshell calcified thymoma that “hatched” after 4 years of follow-up. Pathologically, it revealed that sarcoidosis accompanied this case of thymoma, which might cause in calcification. Case presentation The patient was a 68-year-old female. A 20-mm anterior mediastinal nodule completely covered with calcification was noted in an annual health check-up. However, as the nodule did not change during 6 months of follow-up, she discontinued regular examinations. Four years later, an abnormality in her chest X-ray was noted again. The tumor grew outside the calcification to reach 63 mm. She underwent resection of this anterior mediastinal tumor. Pathologically, the tumor was diagnosed as thymoma of type B1 in the WHO classification. The histology of the tumor inside and outside of the calcification was not different, suggesting that the tumor grew from the inside of the calcification. The calcification was located within the fibrotic capsule of thymoma. Sarcoidosis also presented in her lung and mediastinal lymph nodes. Conclusions Although the mechanism of calcification of the capsule was not clear, sarcoidosis might be related to this case because macrophage accumulation and altered lipid metabolism in sarcoidosis present with similar dystrophic calcification. |
| Databáze: | OpenAIRE |
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