Efficacy of the Treatments Used in Multiple Sclerosis: From Meta-analysis to Number Needed to Treat
| Autor: | Francisco Jódar-Sánchez, Nuria García-Agua Soler, Guillermo Izquierdo-Ayuso, Guillermo Navarro-Mascarell, Ana C. Montesinos-Gálvez, Antonio García-Ruiz, Francisco Martos-Crespo, Manuel Correa |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Multiple Sclerosis Placebo law.invention 03 medical and health sciences Disability Evaluation 0302 clinical medicine Randomized controlled trial law Recurrence Internal medicine medicine Humans Pharmacology (medical) 030212 general & internal medicine Randomized Controlled Trials as Topic Pharmacology Expanded Disability Status Scale business.industry Multiple sclerosis Odds ratio medicine.disease Confidence interval Meta-analysis Number needed to treat Neurology (clinical) business 030217 neurology & neurosurgery Immunosuppressive Agents |
| Zdroj: | Clinical neuropharmacology. 40(1) |
| ISSN: | 1537-162X |
| Popis: | The aim of this study was to analyze the efficacy of drugs used in relapsing-remitting multiple sclerosis, first- and second-line drugs, using the number needed to treat (NNT) as a measure of efficacy. Methods Data from randomized clinical trials were analyzed for 3 categories of clinical efficacy outcomes: relapse, change in Expanded Disability Status Scale, and number of new lesions in magnetic resonance imaging. Meta-analysis results are expressed as odds ratios. Results The global odds ratio was 0.41 (95% confidence interval [CI], 0.34-0.49). For analyzed clinical outcomes, the odds ratio was less for second-line drugs (odds ratio, 2.0). For all studied clinical conditions, in the control group, 47 of 100 patients do not get benefits, compared with 25 (95% CI, 18-32 patients) of 100 for the active treatment group. The NNT was 5 patients (95% CI, 4-7 patients). For the proportion of patients free of relapses, in the control group, 56 of 100 patients had a relapse at 2 years, compared with 37 of 100 patients in the treatment group, with an NNT of 6 patients (95% CI, 5-8 patients). Conclusions Active treatments produced statistically significant improvements compared with placebo. |
| Databáze: | OpenAIRE |
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