A new bactericidal lead structure for the protection of materials
| Autor: | Wolfgang Kreiss, Oliver Kretschik, Guenther Eberz, Hermann Uhr, Johannes Kaulen, Rainer Bruns, Martin Kugler, Erasmus Vogl, Peter Wachtler |
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| Rok vydání: | 2005 |
| Předmět: |
Biocide
Clinical Biochemistry Pharmaceutical Science Microbial Sensitivity Tests Biochemistry Chemical synthesis Structure-Activity Relationship Broad spectrum Lead (geology) Drug Discovery Structure–activity relationship Organic chemistry Amines Molecular Biology Biological evaluation Bacteria Bicyclic molecule Chemistry Organic Chemistry Biological activity General Medicine Bridged Bicyclo Compounds Heterocyclic Combinatorial chemistry Lead structure Molecular Medicine Amine gas treating Disinfectants |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 15:625-629 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2004.11.036 |
| Popis: | Our search for a new broad spectrum bactericide for preserving materials lead to the discovery of a highly active bicyclic amine (1) and a number of derivatives. The synthesis and biological evaluation as well as a first toxicological assessment of these compounds are described. Compound 1 shows strong bactericidal activity down to levels of below 100 ppm but unfortunately increases the number of mutations in Ames tests. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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