Integrated metabolomics, lipidomics, and genomics reveal the presence of a new biomarker, butanediol glucuronide, associated with the activation of Liver ketogenesis and lipid oxidation by tomato-based sofrito in obese rats
| Autor: | José Fernando Rinaldi de Alvarenga, Mar Garcia-Aloy, Marynka Ulaszewska, Sebastian Zagmutt, Marta Perez-Montero, Urska Vrhovsek, Rosa M. Lamuela-Raventós, Rosalia Rodriguez-Rodriguez |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Physiology
Clinical Biochemistry 616.4 Obesidad Biochemistry Dieta mediterrània Lipidòmics Mediterranean diet Metabolomics Obesity Settore CHIM/10 - CHIMICA DEGLI ALIMENTI Molecular Biology Ketogenesis Glucurònid de butandiol Butanediol glucuronide Cell Biology Metabolómica Lipidómica Dieta mediterránea obesity ketogenesis metabolomics lipidomics butanediol glucuronide Metabolòmica Cetogénesis Lipidomics Obesitat Glucurónido de butanodiol Cetogènesi |
| Zdroj: | Antioxidants; Volume 11; Issue 11; Pages: 2165 |
| Popis: | The increasing prevalence of obesity worldwide has promoted research on human metabolism and foods such as sofrito, a tomato and olive oil-based sauce from the Mediterranean diet, has shown beneficial effects on obesity and related complications. Sofrito has been associated with better cardiovascular health, metabolic syndrome, and anti-inflammatory effects. The aim of this study was to understand how sofrito intake could contribute to the control of energy metabolism in obese rats. For this purpose, integrative untargeted lipidomics, metabolomics, and targeted gene expression approaches were used in the liver and adipose tissue to identify metabolic changes and the mechanism of action promoted by sofrito intake. A new biomarker was identified in the liver, butanediol glucuronide, an indicator of ketogenic activation and lipid oxidation after the sofrito intervention. Gene expression analysis revealed an increase in the uptake and liver oxidation of lipids for energy production and ketogenesis activation as fuel for other tissues in sofrito-fed animals. Sofrito altered the lipidomic profile in the fat depots of obese rats. This multiomics study identifies a new biomarker linked to the beneficial actions of sofrito against obesity and provides further insight into the beneficial effect of the Mediterranean diet components. info:eu-repo/semantics/publishedVersion |
| Databáze: | OpenAIRE |
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