PACAP interactions in the mouse brain: Implications for behavioral and other disorders
| Autor: | George K. Acquaah-Mensah, Ronald C. Taylor, Sanjiv V. Bhave |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Gene isoform
Adenylate kinase CREB Cyclase Mice Genetics Animals Gene Regulatory Networks Protein Interaction Maps MAPK1 ADCY7 biology Microarray analysis techniques Mental Disorders Brain General Medicine Microarray Analysis Pituitary adenylate cyclase-activating peptide biology.protein Pituitary Adenylate Cyclase-Activating Polypeptide Neuroscience Algorithms hormones hormone substitutes and hormone antagonists Adenylyl Cyclases Signal Transduction |
| Zdroj: | Gene. 491:224-231 |
| ISSN: | 0378-1119 |
| DOI: | 10.1016/j.gene.2011.09.017 |
| Popis: | As an activator of adenylate cyclase, the neuropeptide Pituitary Adenylate Cyclase Activating Peptide (PACAP) impacts levels of cyclic AMP, a key second messenger available in brain cells. PACAP is involved in certain adult behaviors. To elucidate PACAP interactions, a compendium of microarrays representing mRNA expression in the adult mouse whole brain was pooled from the Phenogen database for analysis. A regulatory network was computed based on mutual information between gene pairs using gene expression data across the compendium. Clusters among genes directly linked to PACAP, and probable interactions between corresponding proteins were computed. Database "experts" affirmed some of the inferred relationships. The findings suggest ADCY7 is probably the adenylate cyclase isoform most relevant to PACAP's action. They also support intervening roles for kinases including GSK3B, PI 3-kinase, SGK3 and AMPK. Other high-confidence interactions are hypothesized for future testing. This new information has implications for certain behavioral and other disorders. |
| Databáze: | OpenAIRE |
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