Renal hemodynamic effects of relaxin in humans
| Autor: | John M. Davison, Kirk P. Conrad, Marie C. Smith, Lee A. Danielson |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Adolescent Renal function Stimulation Luteal phase Primary Ovarian Insufficiency urologic and male genital diseases Kidney General Biochemistry Genetics and Molecular Biology History and Philosophy of Science Internal medicine Follicular phase Medicine Humans reproductive and urinary physiology Menstrual Cycle Relaxin Pregnancy urogenital system business.industry General Neuroscience Ovary Hemodynamics Estrogens medicine.disease Endocrinology Renal blood flow Gestation Female business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Annals of the New York Academy of Sciences. 1041 |
| ISSN: | 0077-8923 |
| Popis: | Rat studies have convincingly demonstrated the essential role of the ovarian hormone relaxin in mediating gestational renal hemodynamic and osmoregulatory changes in that species. We describe a model in nonpregnant volunteers using exogenous hCG to stimulate the production and release of ovarian relaxin in order to assess renal hemodynamic responses. Women (n = 10) were serially studied +/- hCG stimulation during menstrual cycles with measurement of inulin, PAH, and neutral dextran clearances (to determine glomerular filtration rate [GFR], renal plasma flow [RPF], and glomerular porosity, respectively). Controls were women without ovarian function (n = 6) and men (n = 10). GFR and RPF were increased in the luteal phase compared to the follicular phase (15.3% increase in GFR, P < 0.005; 17.8% increase in RPF, P < 0.05). In controls, GFR and RPF were not significantly different between study occasions. Although exogenous hCG did not stimulate relaxin secretion in women without ovarian function or in men, it did so in normal women, but not into the pregnancy range. In no group were renal hemodynamics augmented by administered hCG. In naturally occurring cycles, increased serum relaxin is associated with augmented renal hemodynamics. As luteal stimulation with hCG failed to yield pregnancy relaxin levels, the use of exogenous relaxin for human administration is needed to further elucidate the renal vasodilatory properties of relaxin. |
| Databáze: | OpenAIRE |
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