Microvascular Injury, Thrombosis, Inflammation, and Apoptosis in the Pathogenesis of Heatstroke
| Autor: | Rafaat El-Sayed, Muhammad A. Chishti, Falah Al-Mohanna, Abderrezak Bouchama, George T. Roberts, Futwan Al-Mohanna, Hazem Ghebeh |
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| Rok vydání: | 2008 |
| Předmět: |
Pathology
medicine.medical_specialty Heat Stroke Apoptosis Blood Pressure Inflammation Heat Stress Disorders Body Temperature Thromboplastin Pathogenesis biology.animal von Willebrand Factor medicine Animals Disseminated intravascular coagulation biology Vascular disease business.industry Heatstroke Thrombosis Disseminated Intravascular Coagulation medicine.disease Disease Models Animal Blood pressure Papio hamadryas Endothelium Vascular medicine.symptom Cardiology and Cardiovascular Medicine business Baboon |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 28:1130-1136 |
| ISSN: | 1524-4636 1079-5642 |
| DOI: | 10.1161/atvbaha.107.158709 |
| Popis: | Objective— Severe heatstroke is a leading cause of morbidity and mortality during heat waves. The pathogenesis of tissue injury, organ failure, and death in heatstroke is not well understood. Methods and Result— We investigated the pathways of heatstroke-induced tissue injury and cell death in anesthetized baboons ( Papio hamadyras ) subjected to environmental heat stress until core temperature attained 42.5°C (moderate heatstroke; n=3) or onset of severe heatstroke (n=4) signaled by a fall in systolic blood pressure to Conclusion— These data suggested that microvascular injury, thrombosis, inflammation, and apoptosis may play an important role in the pathogenesis of heatstroke injury. |
| Databáze: | OpenAIRE |
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