Urinary excretion of albumin and retinol-binding protein in lithium-treated patients: a longitudinal study
| Autor: | J. Holm, L. Hemmingsen, H. V. Jensen, E. M. Christensen, H. Aggernæs |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Lithium (medication) Metabolic Clearance Rate Renal function Kidney Function Tests Excretion chemistry.chemical_compound Lithium Carbonate Internal medicine medicine Albuminuria Humans Creatinine Proteinuria business.industry Lithium carbonate Albumin Middle Aged Retinol-Binding Proteins Psychiatry and Mental health Retinol binding protein Endocrinology chemistry Delayed-Action Preparations Female medicine.symptom business medicine.drug |
| Zdroj: | Acta psychiatrica Scandinavica. 85(6) |
| ISSN: | 0001-690X |
| Popis: | The urinary excretion of albumin and retinol-binding protein was determined by means of sensitive immunochemical methods in a 2-year longitudinal study of 22 lithium-treated patients. During lithium treatment, there were no significant changes in the median albumin:creatinine ratios or retinol-binding protein:creatinine ratios. However, the median albumin:creatinine ratios were significantly higher in lithium-treated patients than in 22 normal subjects, which indicates that glomerular permeability is increased; no correlation with serum lithium level or duration of lithium treatment could be shown. In patients treated with slow-release tablets, the urinary excretion of albumin was significantly higher after 2 years than in patients given lithium carbonate. The median retinol-binding protein:creatinine ratios did not differ significantly between lithium-treated patients and normal subjects, suggesting that lithium does not affect the catabolism of low-molecular-weight proteins in the proximal tubules. In conclusion, the study supports the hypothesis that lithium treatment produces a small but significant and nonprogressive elevation of the urinary excretion of albumin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text