Expression of fatty acid binding protein in the liver during pregnancy and lactation in the rat
| Autor: | Nathan M. Bass, R. M. Kaikaus, C. Berges, Hélène Carlier, A. Mallordy, Philippe Besnard, A. Bernard, Laurent Foucaud |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Transcription Genetic Biophysics Gene Expression Nerve Tissue Proteins Biology Fatty Acid-Binding Proteins Myelin P2 Protein Biochemistry Fatty acid-binding protein Liver Fatty Acid-Binding Protein Endocrinology Pregnancy Lactation Internal medicine medicine Animals Rats Wistar Gene Fatty Acids medicine.disease Neoplasm Proteins Rats Cytosol medicine.anatomical_structure Mrna level Liver Gestation lipids (amino acids peptides and proteins) Female Carrier Proteins Energy Intake Fatty Acid-Binding Protein 7 |
| Zdroj: | Biochimica et biophysica acta. 1258(2) |
| ISSN: | 0006-3002 |
| Popis: | Expression of the liver fatty acid binding protein (L-FABP) has been studied in the liver of pregnant and lactating rats. The L-FABP concentration found in the cytosol by immuno-enzymatic assay (ELISA) was consistently higher in the dams during the pregnancy and the lactation than in the age-matched virgin females. Paradoxically, a decrease in the L-FABP mRNA level occurred in the maternal liver during the last days of the gestation. This level remained low on days 7 and 14 of the lactation. Since the transcription rate of the L-FABP gene was unchanged in the maternal liver, these data suggest a post-transcriptional regulation of the L-FABP during pregnancy and lactation in the rat. The nutritional adaptations occurring during pregnancy and lactation are not involved in this regulation since a chronic maternal food-restriction failed to correct these modifications. The mechanism of this regulation is presently unknown, but possibilities include hormonally mediated effects. |
| Databáze: | OpenAIRE |
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