Seasonal Variation in Genome-Wide DNA Methylation Patterns and the Onset of Seasonal Timing of Reproduction in Great Tits
| Autor: | Irene Verhagen, Arild Husby, Marcel E. Visser, Heidi M. Viitaniemi, Kees van Oers, Antti Honkela |
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| Přispěvatelé: | Organismal and Evolutionary Biology Research Programme, Probabilistic Mechanistic Models for Genomics research group / Antti Honkela, Biostatistics Helsinki, Department of Public Health, Department of Mathematics and Statistics, Helsinki Institute for Information Technology, Animal Ecology (AnE) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
THYROID-HORMONE NATURAL VARIATION 01 natural sciences Genome Epigenesis Genetic Songbirds PHENOLOGY Parus major WILD BIRD media_common 0303 health sciences CLIMATE-CHANGE DNA methylation Phenology Reproduction Temperature international 1181 Ecology evolutionary biology Trait Female Seasons laying date Research Article EXPRESSION media_common.quotation_subject Biology complex mixtures 010603 evolutionary biology 03 medical and health sciences PHENOTYPIC PLASTICITY medicine Genetics Animals Epigenetics Genetik Ecology Evolution Behavior and Systematics 030304 developmental biology Phenotypic plasticity RRBS epigenetics timing of reproduction Seasonality equipment and supplies medicine.disease GENE EVOLUTION Evolutionary biology bacteria |
| Zdroj: | Genome Biology and Evolution, 11(3), 970-983 Genome Biology and Evolution 11 (2019) 3 Genome Biology and Evolution Genome Biology and Evolution, 11(3). Oxford University Press |
| ISSN: | 1759-6653 |
| Popis: | In seasonal environments, timing of reproduction is a trait with important fitness consequences, but we know little about the molecular mechanisms that underlie the variation in this trait. Recently, several studies put forward DNA methylation as a mechanism regulating seasonal timing of reproduction in both plants and animals. To understand the involvement of DNA methylation in seasonal timing of reproduction, it is necessary to examine within-individual temporal changes in DNA methylation, but such studies are very rare. Here, we use a temporal sampling approach to examine changes in DNA methylation throughout the breeding season in female great tits (Parus major) that were artificially selected for early timing of breeding. These females were housed in climate-controlled aviaries and subjected to two contrasting temperature treatments. Reduced representation bisulfite sequencing on red blood cell derived DNA showed genome-wide temporal changes in more than 40,000 out of the 522,643 CpG sites examined. Although most of these changes were relatively small (mean within-individual change of 6%), the sites that showed a temporal and treatment-specific response in DNA methylation are candidate sites of interest for future studies trying to understand the link between DNA methylation patterns and timing of reproduction. © The Author(s) 2019. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com. |
| Databáze: | OpenAIRE |
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