Increased levels of serum granzyme-B is associated with insulin resistance and increased cardiovascular risk in adolescent polycystic ovary syndrome patients
| Autor: | Aytekin Tokmak, Efser Oztas, Sibel Ozler, Fatmanur Hacievliyagil Kazanci, Halil İbrahim Yakut, Merve Ergin, Nuri Danisman, Nafiye Yilmaz, Huseyin Tugrul Celik |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Blood Glucose medicine.medical_specialty Adolescent medicine.medical_treatment Granzymes 03 medical and health sciences Young Adult 0302 clinical medicine Insulin resistance Risk Factors Internal medicine medicine Humans Insulin 030219 obstetrics & reproductive medicine business.industry Perforin Case-control study Obstetrics and Gynecology medicine.disease Obesity Polycystic ovary Lipids Granzyme B 030104 developmental biology Endocrinology Reproductive Medicine Cardiovascular Diseases Case-Control Studies Female Metabolic syndrome Insulin Resistance business Body mass index Polycystic Ovary Syndrome |
| Zdroj: | European journal of obstetrics, gynecology, and reproductive biology. 198 |
| ISSN: | 1872-7654 |
| Popis: | Our aim was to determine serum perforin and granzyme-B levels in adolescent PCOS patients, and to investigate whether they are associated with some of the insulin sensitivity, obesity and cardiovascular (CV) risk markers and metabolic syndrome.A case-control study was carried out including a total of 172 adolescents (83 PCOS patients and 89 age-matched healthy controls). Participants were recruited consecutively. Homeostasis model assessment (HOMA-IR), lipid parameters, and anthropometric measurements were determined. Serum perforin and granzyme B levels were measured by commercially available ELISA kits. HOMA-IR3.16 was considered to indicate the presence of insulin resistance. Logistic regression analysis was applied for the predictive value of granzyme-B for increased CV risk in PCOS patients.As body mass index (BMI) of the PCOS patients was significantly higher than the controls (median 24.6kg/m(2) and 21.4kg/m(2), respectively, p0.001) all parameters were evaluated after adjustment for BMI. Adolescents with PCOS had significantly higher levels of fasting glucose, insulin, HOMA-IR and granzyme-B when compared with controls. According to the results of logistic regression analysis, granzyme-B levels were found to be significantly associated with increased HOMA-IR (OR=6.120, 95% CI: 2.352-15.926, p0.001) in adolescent PCOS patients. Additionally, elevated levels of serum granzyme-B were predictive for increased CV risk in PCOS patients (OR=0.237, 95% CI: 0.091-0.616, p=0.003).Increased levels of serum granzyme-B are independently associated with insulin resistance and also with increased CV risk in adolescent polycystic ovary syndrome patients. |
| Databáze: | OpenAIRE |
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