Age-dependent measures of anxiety and cognition in male histidine decarboxylase knockout (Hdc−/−) mice
| Autor: | Theodore S. Benice, Jacob Raber, Hiroshi Ohtsu, Summer F. Acevedo, Angela Rizk-Jackson |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Aging medicine.medical_specialty Elevated plus maze Time Factors Spatial Behavior Water maze Anxiety Histidine Decarboxylase Rotarod performance test Open field Developmental psychology Mice Cognition Internal medicine Avoidance Learning medicine Animals Maze Learning Molecular Biology Swimming Mice Knockout Analysis of Variance Behavior Animal General Neuroscience Age Factors Histaminergic Histidine decarboxylase Mice Inbred C57BL Endocrinology Rotarod Performance Test Exploratory Behavior Neurology (clinical) medicine.symptom Hypoactivity Psychology Locomotion Psychomotor Performance Developmental Biology |
| Zdroj: | Brain Research. 1071:113-123 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2005.11.067 |
| Popis: | Histidine decarboxylase deficient (Hdc(-/-)) and wild-type male mice on the C57Bl6/J background were used to determine the role of histamine in brain function. 3-5 (Y) and 12-14 (MA) month-old Hdc(-/-) mice showed hypoactivity and increased measures of anxiety in the open field, light-dark, elevated plus-maze, and elevated zero maze tests. Y Hdc(-/-) mice showed superior performance in the hidden sessions of the water maze and passive avoidance memory retention. In contrast, Y Hdc(-/-) mice were impaired in novel location recognition, spent less time searching in the target quadrant and more time searching in the outer zone of the water maze during the probe trials. These behaviors are likely due to increased measures of anxiety and are not found in MA Hdc(-/-) mice. These data support a role for histamine in anxiety and cognition and underline the importance of considering age and potential effects on measures of anxiety in the interpretation of the role of histaminergic neurotransmission in cognitive function. |
| Databáze: | OpenAIRE |
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