Lymphocytic plasmocytoid lymphoma with a three-banded gammopathy: Reactivity of one of these paraproteins with cytomegalovirus
| Autor: | Köhler M, N Wernert, H. Daus, P Schlimmer, C Köhler, P G Scheurlen |
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| Rok vydání: | 1987 |
| Předmět: |
Immunofixation
Pathology medicine.medical_specialty Cytomegalovirus Antibodies Viral Antigen-Antibody Reactions Immunoglobulin lambda-Chains Antigen immune system diseases hemic and lymphatic diseases Gammopathy Immunopathology Humans Medicine Antigens Viral Aged biology business.industry virus diseases Hematology General Medicine Blood Protein Electrophoresis medicine.disease Leukemia Lymphocytic Chronic B-Cell Lymphoma Leukemia Immunology biology.protein Female Paraproteins Antibody business |
| Zdroj: | Blut. 54:25-32 |
| ISSN: | 1432-0584 0006-5242 |
| DOI: | 10.1007/bf00326023 |
| Popis: | We report the case of a 70-year-old woman suffering from small lymphocytic, plasmocytoid lymphoma with abdominal lymphomas and infiltration of the lung and the bone marrow. A three-banded, IgG lambda, IgM lambda and IgA lambda-paraproteinemia was determined using immunofixation. Because of the patient's high antibody titre against cytomegalovirus (CMV), the possible reactivity of these paraproteins with CMV was studied. The immunoglobulins were transferred to nitrocellulose sheets by a contact diffusion blotting system. CMV was applied to these sheets and the IgG lambda-paraprotein was shown to bind CMV. The reactivity of only one of the paraproteins with CMV suggests an oligoclonal origin of this gammopathy. In addition to the malignant disease an abnormal immune response to a CMV infection could be the cause of this three-banded gammopathy. |
| Databáze: | OpenAIRE |
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