Changes in epilepsy burden after onchocerciasis elimination in a hyperendemic focus of western Uganda: a comparison of two population-based, cross-sectional studies
| Autor: | Henry Onen, C. Kaiser, Joseph Nelson Siewe Fodjo, Donozio Kisembo, George Asaba, Frank Mubiru, Robert Colebunders, Nolbert Gumisiriza |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Adolescent Endemic Diseases Cross-sectional study 030231 tropical medicine Physical examination Onchocerciasis Young Adult 03 medical and health sciences Epilepsy 0302 clinical medicine Surveys and Questionnaires Environmental health Prevalence Animals Humans Medicine Uganda Onchocerca Disease Eradication Young adult Child medicine.diagnostic_test biology Transmission (medicine) business.industry Incidence Incidence (epidemiology) Infant Newborn Infant Middle Aged medicine.disease biology.organism_classification Cross-Sectional Studies Infectious Diseases Child Preschool Female Human medicine business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | The lancet infectious diseases |
| ISSN: | 1473-3099 |
| Popis: | Background In 1994, prevalence and incidence of epilepsy were high in the Itwara onchocerciasis focus (western Uganda), and cases of nodding and Nakalanga syndrome were documented. Onchocerciasis transmission was interrupted successfully in 2001. 17 years later, we re-investigated the epilepsy burden in this area. Methods From Dec 11 to Dec 15, 2018, a door-to-door survey was done in the three villages (Kabende Centre, Masongora South, and Rwesenene) with the highest epilepsy rates in 1994 to identify people with suspected epilepsy. Epilepsy diagnoses were confirmed by an interview and physical examination by a study clinician. The prevalence and incidence of epilepsy were measured using methods consistent with those used in 1994. Results from 2018 were compared with those from 1994. Findings The overall crude prevalence of epilepsy in the study villages decreased from 3.0% (35 of 1169) in 1994 to 1.2% (27 of 2325) in 2018 (p=0.0002), with a concomitant decrease in the proportion of people with epilepsy with unknown cause (p=0.037). Between 1994 and 2018, the overall incidence of epilepsy decreased from 418 cases per 100 000 personyears (95% CI 265-626) to 73 new cases per 100 000 person-years (32-114; p |
| Databáze: | OpenAIRE |
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