Paratrend sensor as a novel method for continuous monitoring of hepatic microperfusion
| Autor: | J Hess, E Escher, Stefan Ludwig, H. Witzigmann, Barbara Armann, Dirk Uhlmann, G Gaebel, Uta-Carolin Pietsch, J. Hauss |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Swine Partial Pressure medicine.medical_treatment Ischemia Hemodynamics Biosensing Techniques Liver transplantation chemistry.chemical_compound Internal medicine medicine Animals Monitoring Physiologic Transplantation business.industry Microcirculation Oxygenation Carbon Dioxide Hydrogen-Ion Concentration Laser Doppler velocimetry medicine.disease Surgery Oxygen medicine.anatomical_structure chemistry Models Animal Cardiology business Perfusion Indocyanine green Liver Circulation Artery |
| Zdroj: | Transplantation Proceedings. 34:3339-3341 |
| ISSN: | 0041-1345 |
| DOI: | 10.1016/s0041-1345(02)03588-1 |
| Popis: | DESPITE THE REMARKABLE progress in liver tranplantation, 7% of graft losses occur due to vascular complications, especially of the hepatic artery. The continuous monitoring of hepatic microcirculation following liver transplantation represents a technique for early detection of vascular complications. Multiple methods have been employed to measure liver blood flow in vivo. However, most of the methods, like indocyanine green clearance, indicator dilution, or fractionation techniques, are limited by an indirect approach and the lack of repetitive sampling. Electromagnetic and Doppler flow probes and laser flowmetry allow direct quantification of whole organ blood flow but have the drawback of short-term intraoperative application, especially in the clinical setting. All of the methods mentioned above preclude continuous monitoring of hepatic perfusion in patients over several days after liver transplantation. In contrast, assessment of hepatic pCO2, pO2, and pH with the Paratrend has the potential to provide a continuous real-time quantitative monitoring of liver microcirculation with little invasiveness. Measurement of hepatic tissue oxygenation has been shown to correlate significantly with microcirculatory impairment and liver dysfunction induced by vascular problems. Additional measurement of pCO2 and pH permits assessment of tissueacid base and the metabolic state in the liver. Up to now the Paratrend technique was not inserted in parenchymal organs except for brain/spinal cord monitoring and a hemorrhagic shock study in the liver. The aim of the present study was to evaluate the Paratend technique for continuous quantitation of hepatic microcirculation in a preclinical animal model of hepatic artery and portal vein occlusion. The Paratrend technique was compared with the established methods of laser Doppler flowmetry and pO2 measurement by the Licox device. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect