Two New Cerebroside Metabolites from the Marine Fungus Hortaea werneckii

Autor:	Yung‐Husan Chen, Xiuna Wu, Li Xu, Mohamed El‐Shazly, Chuwen Ma, Shijie Yuan, Panpan Wang, Lianzhong Luo
Rok vydání:	2022
Předmět:	Cerebrosides Exophiala Molecular Medicine Bioengineering General Chemistry General Medicine Molecular Biology Biochemistry
Zdroj:	Chemistry & Biodiversity. 19
ISSN:	1612-1880 1612-1872
DOI:	10.1002/cbdv.202200008
Popis:	Two new cerebroside metabolites were isolated from the fermented sponge-derived fungus extract of Hortaea werneckii. They were hortacerebroside A (1) ((2R,3E)-N-[(2S,3R,4E,8E)-1-(β-D-glucopyranosyloxy)-3-hydroxy-9-methylhenicosa-4,8-dien-2-yl]-2-hydroxypentadec-3-enamide) and hortacerebroside B (2) ((2R)-N-[(2S,3R,4E,8E)-1-(β-D-glucopyranosyloxy)-3-hydroxy-9-methylhenicosa-4,8-dien-2-yl]-2-hydroxypentadecanamide). Their structures were elucidated by spectroscopic analysis and by comparison of the spectroscopic data with those of related cerebroside analogs. These two compounds showed significant inhibitory effect on NO produced by lipopolysaccharide (LPS) stimulated RAW 264.7 macrophages. The IC
Databáze:	OpenAIRE
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