Sequence analysis of two exons from the murine dystrophin locus

Autor:	Andrew J. Greenfield, Mark K. Maconochie, Stephen D.M. Brown
Rok vydání:	1991
Předmět:	Genetics Base Sequence biology Sequence analysis Molecular Sequence Data Restriction Mapping Nucleic acid sequence Locus (genetics) DNA Exons Molecular biology Dystrophin Mice Exon Protein sequencing Complementary DNA biology.protein Consensus sequence Animals Amino Acid Sequence Sequence Alignment
Zdroj:	Mammalian Genome. 2:64-68
ISSN:	1432-1777 0938-8990
Popis:	We have isolated two genomic clones from the murine dystrophin locus, containing single exons encoding protein sequence from the putative actin-binding domain of the amino-terminus and the terminal portion of the triple helical domain. Using interspecific backcross progeny mice, both clones were shown to be X-linked. Sequence analysis indicated that the amino-terminal clone contains a 173 bp exon exhibiting 90% nucleotide sequence identity to human dystrophin exon 6, whilst the C-terminal clone contains a 61 bp exon with 93% nucleotide sequence identity to the human cDNA sequence.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d76ab6a8c5160900377aa8a92e2c22 https://doi.org/10.1007/bf00570441 Zobrazit plný text záznamu