Low mannose-binding lectin complement activation function is associated with predisposition to Legionnaires' disease
| Autor: | D. Spilsbury, John Carnie, J. Stubbs, Jennie A. Leydon, Damon P. Eisen, Benjamin P Howden |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Translational Studies Immunology Enzyme-Linked Immunosorbent Assay chemical and pharmacologic phenomena Disease Mannose-Binding Lectin Severity of Illness Index Legionella pneumophila Microbiology medicine Humans Immunology and Allergy Mannan-binding lectin biology Respiratory disease Outbreak Complement C4 Complement Pathway Mannose-Binding Lectin Prognosis bacterial infections and mycoses biology.organism_classification medicine.disease MBL deficiency Complement system Case-Control Studies Female Legionnaires' disease Disease Susceptibility Legionnaires' Disease |
| Zdroj: | Clinical and Experimental Immunology. 149:97-102 |
| ISSN: | 1365-2249 0009-9104 |
| DOI: | 10.1111/j.1365-2249.2007.03390.x |
| Popis: | Summary Innate immune system deficiency may predispose to severe infections such as Legionnaires' disease. We have investigated the role of mannose-binding lectin (MBL) deficiency in the Melbourne Aquarium Legionnaires' disease outbreak. Serum samples from patients and controls that were exposed but shown to be uninfected from the Melbourne Aquarium Legionnaires' disease outbreak were tested for MBL function (C4 deposition) and level (mannan-binding). MBL function was lower in Legionnaires' disease cases than in age- and sex-matched uninfected, exposed controls. The frequency of MBL deficiency with C4 deposition |
| Databáze: | OpenAIRE |
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