In situ procedure for high-efficiency computational modeling of atrial fibrillation reflecting personal anatomy, fiber orientation, fibrosis, and electrophysiology
| Autor: | Jaehyeok Kim, Byounghyun Lim, Jun Seop Song, Moon Hyung Lee, Hee Tae Yu, Jae Sun Uhm, Hui Nam Pak, Tae Hoon Kim, Minki Hwang, Boyoung Joung, Jung Ki Lee |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Models Anatomic In situ medicine.medical_treatment Fiber orientation lcsh:Medicine Catheter ablation 030204 cardiovascular system & hematology Right atrial Article 03 medical and health sciences 0302 clinical medicine Fibrosis medicine Humans Computer Simulation Heart Atria 030212 general & internal medicine lcsh:Science Aged Retrospective Studies Paroxysmal AF Multidisciplinary business.industry lcsh:R Models Cardiovascular Atrial fibrillation Anatomy Middle Aged medicine.disease Electrophysiology Catheter Ablation Feasibility Studies lcsh:Q Female Electrophysiologic Techniques Cardiac business Interventional cardiology Software |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) |
| ISSN: | 2045-2322 |
| Popis: | We previously reported the feasibility and efficacy of a simulation-guided clinical catheter ablation of atrial fibrillation (AF) in an in-silico AF model. We developed a highly efficient realistic AF model reflecting the patient endocardial voltage and local conduction and tested its clinical feasibility. We acquired > 500 endocardial bipolar electrograms during right atrial pacing at the beginning of the AF ablation procedures. Based on the clinical bipolar electrograms, we generated simulated voltage maps by applying fibrosis and local activation maps adjusted for the fiber orientation. The software’s accuracy (CUVIA2.5) was retrospectively tested in 17 patients and feasibility prospectively in 10 during clinical AF ablation. Results: We found excellent correlations between the clinical and simulated voltage maps (R = 0.933, p in situ procedural computing time from the clinical data acquisition to wave-dynamics analyses of 48.2 ± 4.9 min. All virtual analyses were successfully achieved during clinical PVI procedures. We developed a highly efficient, realistic, in situ procedural simulation model reflective of individual anatomy, fiber orientation, fibrosis, and electrophysiology that can be applied during AF ablation. |
| Databáze: | OpenAIRE |
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