Acute acyclovir neurotoxicity in a hemodialyzed child
| Autor: | Dawn K. Strong, Diane Hebert |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Nephrology
medicine.medical_specialty viruses medicine.medical_treatment Acyclovir Renal function Antiviral Agents Gastroenterology Postoperative Complications Renal Dialysis Internal medicine medicine Humans heterocyclic compounds Aciclovir Kidney transplantation Coma business.industry Neurotoxicity virus diseases medicine.disease Kidney Transplantation Lymphoproliferative Disorders Surgery Child Preschool Pediatrics Perinatology and Child Health Toxicity Female Hemodialysis Nervous System Diseases medicine.symptom business medicine.drug |
| Zdroj: | Pediatric Nephrology. 11:741-743 |
| ISSN: | 1432-198X 0931-041X |
| DOI: | 10.1007/s004670050379 |
| Popis: | A 5-year-old girl with a kidney transplant developed post-transplant Epstein-Barr virus-induced lymphoproliferative disease. She was treated with acyclovir, alpha-interferon, and gamma globulin. A transplant nephrectomy was performed on day 4 due to acute rejection and she was started on hemodialysis. The acyclovir dose was decreased at this time. However, 6 days following the start of acyclovir she developed progressively worsening neurological symptoms resulting in a coma on day 8. Fourteen days after acyclovir was begun pre- and post-dose serum concentrations were 7.02 microM and 182.5 microM, respectively. Acyclovir was then discontinued and 2 days later the child's neurological status began to improve. We conclude that acyclovir in children with end-stage renal failure may lead to severe and reversible neurotoxicity, despite acyclovir dosage adjustment based on renal impairment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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