Peptic ulcer disease: one in five is related to neither Helicobacter pylori nor aspirin/NSAID intake

Autor:	C, Charpignon, B, Lesgourgues, A, Pariente, S, Nahon, A, Pelaquier, G, Gatineau-Sailliant, A-M, Roucayrol, A, Courillon-Mallet, C, Bendib
Rok vydání:	2013
Předmět:	Adult Male medicine.medical_specialty Peptic Ulcer Adolescent Population Disease Hospitals General Gastroenterology Helicobacter Infections Young Adult Risk Factors Internal medicine Epidemiology Medicine Humans Pharmacology (medical) Prospective Studies education Prospective cohort study Aged Breath test Aged 80 and over education.field_of_study Aspirin Hepatology medicine.diagnostic_test biology Helicobacter pylori business.industry Anti-Inflammatory Agents Non-Steroidal Middle Aged biology.organism_classification digestive system diseases Hospitalization Breath Tests Concomitant Female France business medicine.drug
Zdroj:	Alimentary pharmacologytherapeutics. 38(8)
ISSN:	1365-2036
Popis:	Summary Background The proportion (and even the reality) of peptic ulcer disease (PUD) not related to H. pylori or NSAID/aspirin is debated. Aim To analyse the current epidemiological and clinical characteristics of peptic ulcer disease in French general hospitals. Methods Prospective multicentre study of patients with peptic ulcer disease in 32 French general hospitals over 1 year. H. pylori status was assessed by histology, and/or serology and/or C13-urea breath test. NSAID/aspirin intake (obtained by direct interview) and data about concomitant diseases were collected on the day of endoscopy. Results Nine hundred and thirty-three patients were selected during the year 2009. After exclusion of 118 patients with only erosive duodenitis, 24 with major missing data, 13 with other causes of ulcer and 65 negative for H. pylori by only one test, 713 patients were classified into four groups: 285 (40.0%) had only H. pylori infection; 133 (18.7%) only gastrotoxic drugs; 141 (19.8%) had both and 154 (21.6%) neither H. pylori infection nor gastrotoxic drug intake (‘idiopathic ulcers’). Patients with idiopathic ulcers differed in many ways both from H. pylori and NSAID/aspirin groups. However, multivariate analysis identified only three independent predictors: age, French metropolitan origin and the presence of comorbidities. Conclusion In a general hospital-based population in France, peptic ulcer disease appears idiopathic in a fifth of cases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d36609dd8a2e73a76e877b0525b1b7 https://pubmed.ncbi.nlm.nih.gov/23981105 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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