Periodontitis deteriorates peripheral arterial disease in Japanese population via enhanced systemic inflammation
| Autor: | Hidetoshi Kumagai, Mitsuaki Isobe, Hiroshi Akazawa, Naho Kobayashi, Hiroki Sato, Norihiko Ashigaki, Norio Aoyama, Yuichi Ikeda, Asuka Yoshida, Yuka Shiheido, Issei Komuro, Tomoya Hanatani, Jun-ichi Suzuki, Yuichi Izumi |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Bleeding on probing Gingiva 030204 cardiovascular system & hematology Systemic inflammation Peripheral Arterial Disease Young Adult 03 medical and health sciences Age Distribution 0302 clinical medicine Risk Factors Internal medicine medicine Humans Ankle Brachial Index Sex Distribution Periodontitis Tokyo Aged Retrospective Studies Aged 80 and over Edentulism Bacteria Arterial stenosis business.industry Incidence Incidence (epidemiology) Angiography 030206 dentistry Middle Aged medicine.disease Antibodies Bacterial Surgery Cardiac surgery Cross-Sectional Studies Disease Progression Female medicine.symptom Cardiology and Cardiovascular Medicine business Dyslipidemia Follow-Up Studies |
| Zdroj: | Heart and Vessels. 32:1314-1319 |
| ISSN: | 1615-2573 0910-8327 |
| Popis: | Peripheral arterial disease (PAD) is a common manifestation of arterial stenosis of the extremity that reduces arterial flow. While patients with periodontitis are at a high risk of PAD, little causal information has been provided to date. To clarify the relationship, we conducted this cross-sectional study. The oral condition of patients with or without PAD, who attended Tokyo Medical and Dental University Hospital, was evaluated. Blood examinations and dental clinical measurements, including number of teeth, probing pocket depth (PPD), bleeding on probing (BOP) and clinical attachment level (CAL) were performed. Chi-square test was performed to compare gender, smoker rate, prevalence of DM, hypertension and dyslipidemia and edentulous rate. Wilcoxon test was used to compare bacterial counts and anti-bacterial antibodies and Student's t test was used to compare the other numerical values. The subjects were patients with (n = 34) or without (n = 956) PAD. We revealed that the PAD patients had more missing teeth (17.5 ± 11.0), a higher rate of edentulism (18%), and higher serum inflammatory factor levels than non-PAD patients (10.9 ± 8.7, 5%, respectively). On the other hand, there was no significant difference between hypertension, dyslipidemia, smoking status, HbA1c, bacterial antibody titers, and bacterial counts between the groups. In conclusion, we clarified that PAD patients had decreased tooth number and worsened oral and periodontal condition with enhanced systemic inflammation. |
| Databáze: | OpenAIRE |
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