Case Report: Misleading Serological Diagnosis of Paracoccidioidomycosis in a Young Patient with the Acute Form Disease: Paracoccidioides brasiliensis or Paracoccidioides lutzii?
| Autor: | Mônica Scarpelli Martinelli Vidal, Vanessa dos Santos Morais, Gil Benard, Gilda Maria Barbaro Del Negro, Adriana Pardini Vicentini, Renata Buccheri, Camila Mika Kamikawa, Gabriel Naves |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Paracoccidioides brasiliensis biology IMUNOHISTOQUÍMICA business.industry Paracoccidioidomycosis 030106 microbiology 030231 tropical medicine Paracoccidioides lutzii Disease medicine.disease biology.organism_classification Paracoccidioides Serology 03 medical and health sciences 0302 clinical medicine Infectious Diseases Antigen Virology Immunology biology.protein Medicine Parasitology Antibody business |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | Negative results in serological routine screening of patients with microbiologically proven Paracoccidioidomycosis (PCM) are occasionally reported. Failure in detecting anti-Paracoccidioides antibodies has been ascribed to factors either related to serological techniques or to the status of the host immune reactivity. Recently, this issue has been renewed by the recognition that the Paracoccidioides genera comprises two species, lutzii and brasiliensis, which have distinct antigenic profiles and, therefore, may elicit different host antibody responses. We describe a patient with the acute form PCM due to Paracoccidioides brasiliensis with negative results on two reference centers' routine screening for P. brasiliensis antibodies, but positive results with Paracoccidioides lutzii antigens. The present case report suggests that antibodies elicited during P. brasiliensis infection recognize antigenic fractions shared by both species, highlighting the difficulties in distinguishing the two infections by means of the currently available routine serological assays. |
| Databáze: | OpenAIRE |
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