SCARB1 rs5888 is associated with the risk of age-related macular degeneration susceptibility and an impaired macular area
| Autor: | Daiva Stanislovaitiene, Algimantas Kriščiukaitis, Vaiva Lesauskaite, Abdonas Tamosiunas, Robertas Petrolis, Vita Lesauskaite, Dalia Zaliuniene, Alina Smalinskiene |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Heterozygote medicine.medical_specialty Genotype Population Single-nucleotide polymorphism Disease Biology Real-Time Polymerase Chain Reaction Polymorphism Single Nucleotide Macular Degeneration 03 medical and health sciences 0302 clinical medicine Gene Frequency Risk Factors Internal medicine medicine Humans Prospective Studies education Prospective cohort study Genotyping Genetics (clinical) Aged Aged 80 and over education.field_of_study Case-control study Scavenger Receptors Class B Macular degeneration medicine.disease eye diseases Surgery Ophthalmology Macular Lesion 030104 developmental biology Case-Control Studies Pediatrics Perinatology and Child Health Disease Progression 030221 ophthalmology & optometry Female Disease Susceptibility |
| Zdroj: | Ophthalmic Genetics. 38:233-237 |
| ISSN: | 1744-5094 1381-6810 |
| DOI: | 10.1080/13816810.2016.1203442 |
| Popis: | Age-related macular degeneration (ARMD), a progressive retinal disease, is responsible for an impaired central vision in about 180 million people worldwide. Current options for ARMD prevention and treatment are limited due to an incomplete understanding of disease etiopathogenesis. We aimed to test the hypothesis that the single nucleotide polymorphism rs5888 of SCARB1 gene reflecting lipid and antioxidant micronutrient metabolism pathways is associated with ARMD susceptibility and to evaluate if there is any relation between SCARB1 rs5888 and the macular lesion area.The prospective case-control study included patients with ARMD (n = 215) and the reference group (n = 238) drawn from a random sample of the Lithuanian population (n = 1436). The genotyping test of SCARB1 rs5888 was carried out using the real-time polymerase chain reaction method.Regression analysis adjusted by gender and age demonstrated that SCARB1 rs5888 TT genotype significantly decreased the odds for ARMD development (OR: 0.61, 95%; CI: 0.380-0.981, p = 0.04). A smoking habit and leading an outdoor life are associated with larger macular lesion areas in ARMD patients (0.54 (0.00-39.06) vs. 3.09 (0.02-19.30) and 0.27 (0.00-34.57) vs. 0.75 (0.00-39.06), respectively). In late stage ARMD subjects with CT genotype, the macular lesion area was larger than in TT carriers (7.64 (0.49-39.06) mmSCARB1 rs5888 and environmental oxidative stress have a prominent role in ARMD susceptibility, early ARMD progression to advanced stage disease and even in the outcome of the disease-an area of macular lesion. |
| Databáze: | OpenAIRE |
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