Optical fiber bio-sensor for phospholipase using liquid crystal
| Autor: | Huihui Lu, Li Zhibin, Tianjin Wen, Zhe Chen, Jianhui Yu, Yunhan Luo, Huadan Zheng, Wenguo Zhu, Heyuan Guan, Jun Zhang, Mengyuan Xie, Yu Zhang, Zhanxiong Fang, Wenjin Long, Shun Long, Jieyuan Tang |
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| Rok vydání: | 2020 |
| Předmět: |
Optical fiber
Materials science Biomedical Engineering Biophysics Optical power 02 engineering and technology Biosensing Techniques Phospholipase 01 natural sciences law.invention Glucose Oxidase law Liquid crystal Electrochemistry Optical Fibers Detection limit business.industry 010401 analytical chemistry General Medicine 021001 nanoscience & nanotechnology 0104 chemical sciences Liquid Crystals Fiber optic sensor Phospholipases Optoelectronics Bio sensor 0210 nano-technology business Biosensor Biotechnology |
| Zdroj: | Biosensorsbioelectronics. 170 |
| ISSN: | 1873-4235 |
| Popis: | A cost-effective and label-free optical fiber sensor was proposed to detect phospholipase A2 (PLA2) in nM concentration. The sensor is made of an alkoxysilane-modified side-polished fiber (SPF) coated with 4′-pentyl-4-cyanobiphenyl (5CB) and self-assembled phospholipid (L-DLPC). It is found that the relative transmission optical power (RTOP) of the fiber sensor decreases due to the 5CB realignment and redistribution induced by the PLA2 hydrolysis of L-DLPC. The response-time at 5 dB RTOP variation exhibits an exponential dependence on PLA2 concentration, allowing us to detect the PLA2 by the 5 dB-response time. This detection method can reduce the detection time. Compare with the traditional copper-grid sensor, the proposed novel fiber sensor has a lower detection limit ( |
| Databáze: | OpenAIRE |
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