Midazolam attenuates ketamine-induced abnormal perception and thought process but not mood changes
| Autor: | Peter S. Lansing, Rachel A. Sheppard, Merritt M. Tolan, Kentaro Tsueda, Manzo Suzuki, Thomas M. Fuhrman, Harrell E. Hurst, Steven Lippmann |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male genetic structures Visual analogue scale medicine.drug_class Midazolam Sedation Blood Pressure Neuropsychological Tests Thinking Hypnotic Double-Blind Method Heart Rate medicine Humans Ketamine Anesthetics Dissociative business.industry General Medicine Middle Aged Affect Anesthesiology and Pain Medicine Mood Anti-Anxiety Agents Sedative Anesthesia NMDA receptor Perception Sleep Stages medicine.symptom Cognition Disorders business Psychomotor Performance medicine.drug |
| Zdroj: | Canadian Journal of Anesthesia/Journal canadien d'anesthésie. 47:866-874 |
| ISSN: | 1496-8975 0832-610X |
| DOI: | 10.1007/bf03019666 |
| Popis: | Purpose: To determine the effects of midazolam, 30 ng·mL−1, on altered perception, mood, and cognition induced by ketamine. Methods: After ketamine was administered to achieve target concentrations of 50, 100, or 150 ng·mL−1 in 11 volunteers, perception, mood, and thought process were assessed by a visual analog scale. Mini-Mental State examination (MMSE) assessed cognition. Boluses of midazolam, 30, 14.5, and 12µg·kg−1, were injected every 30 min to maintain the plasma concentration at 30 ng·mL−1, which was reached 30 min after each injection. Results: Ketamine produced changes in perception about the body (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink