Assessing the in vitro cell based ocular compatibility of contact lens materials

Autor:	William Rhys-Williams, Richard G. A. Faragher, M. Wassall, J.E. Hughes, Andrew W. Lloyd, Geoffrey W. Hanlon, L. Wong
Rok vydání:	2000
Předmět:	Biocompatibility Chemistry In vitro toxicology General Medicine Granulocyte In vitro Cell biology Contact lens Ophthalmology medicine.anatomical_structure Self-healing hydrogels medicine Cell adhesion Optometry Biomedical engineering Cell based
Zdroj:	Contact Lens and Anterior Eye. 23:119-123
ISSN:	1367-0484
Popis:	A series of in vitro assays for determining the biocompatibility of ocular biomaterials have been developed and used to assess the differences in performance of omafilcon A, etafilcon A and nelfilcon A contact lens materials. The assays assessed bacterial attachment, macrophage adhesion, granulocyte adhesion and activation, epithelial cell adhesion and corneal cell contact damage. Overall, omafilcon A was found to be more biocompatible than the other materials although there was no significant difference between the epithelial cell adhesion and granulocyte adhesion and activation on any of the hydrogels. Etailcon A performed less well compared to nelfilcon A and omafilcon A with respect macrophage adhesion and bacterial adhesion. The results indicate that these biological assays can be successfully applied for the testing of contact lens materials and may be particularly useful in the in vitro screening of new extended wear contact lens materials where cell adhesion and activation may have a greater influence on clinical performance.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c87f7a6db5a327b8c583b5d814af80 https://doi.org/10.1016/s1367-0484(00)80004-1 Zobrazit plný text záznamu Full Text from ScienceDirect