Pediatric P‐ANCA vasculitis following COVID‐19
| Autor: | Nastasia Nianiaris, Maria E Imperial, Bugsu Ovunc, Cyrus Shahriary, Yaron Fireizen, Inderpal Randhawa |
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| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pathology medicine.medical_specialty Past medical history diffuse alveolar hemorrhage medicine.diagnostic_test P-ANCA business.industry medicine.medical_treatment Acute kidney injury Case Report Diffuse alveolar hemorrhage Case Reports medicine.disease Pneumonia COVID‐19 P‐ANCA vasculitis Pediatrics Perinatology and Child Health Biopsy medicine Plasmapheresis business Vasculitis |
| Zdroj: | Pediatric Pulmonology |
| ISSN: | 1099-0496 8755-6863 |
| DOI: | 10.1002/ppul.25612 |
| Popis: | Background Perinuclear anti‐neutrophil cytoplasmic antibodies (P‐ANCA) are associated with a multisystem vasculitis affecting small blood vessels in the body. A handful of adult patients who developed vasculitis post‐COVID‐19 have been reported. Although SARS‐CoV‐2 has been shown to drive an exaggerated immune response in the pediatric population, such as in Multisystem Inflammatory Syndrome in Children (MIS‐C), only one case of vasculitis following COVID‐19 has been reported previously in children. Case presentation Seventeen‐year‐old male with a past medical history of COVID‐19 pneumonia two months prior presented with acute kidney injury and diffuse alveolar hemorrhage. Rheumatologic workup revealed P‐ANCA and Myeloperoxidase (MPO) positivity. Kidney biopsy showed necrotizing glomerulonephritis with limited immune complex deposition. Subsequently, he was treated with steroids and plasmapheresis, and ultimately started on cyclophosphamide. Conclusions To our knowledge, this report presents the second reported pediatric case of P‐ANCA/MPO vasculitis following COVID‐19. Highlights Autoimmune development postinfectious process.Autoimmune disease and its association to SARS‐CoV‐2 infection.Pediatric P‐ANCA vasculitis post COVID‐19 |
| Databáze: | OpenAIRE |
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