Influence of Pasteurella tularensis on enzymes involved in energy metabolism in tissues of rats
| Autor: | Gennaro J. Miraglia, John M. Woodward |
|---|---|
| Rok vydání: | 1961 |
| Předmět: |
medicine.medical_specialty
Energy metabolism Aconitase activity Normal values Biology General Biochemistry Genetics and Molecular Biology Microbiology Internal medicine Liver tissue medicine Animals Francisella tularensis Tularemia Hydro-Lyases chemistry.chemical_classification Pasteurella tularensis Fumarase activity Rats Leadership Enzyme Endocrinology chemistry Liver Cortisone Energy Metabolism medicine.drug |
| Zdroj: | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 106 |
| ISSN: | 0037-9727 |
| Popis: | SummaryAconitase and fumarase activity in liver tissue of tularemic rats was demonstrated to be reduced by more than 33% below normal values at height of infection. Administration of cortisone in a concentration of 5 mg per rat per day during infection supported aconitase activity at nearly normal levels for 48 hours but failed to do so beyond that time. Liver fumarase activity of rats treated with cortisone was maintained at only slightly higher levels than observed for the controls. The data presented suggest extensive adrenal involvement in tularemic rats which can be alleviated only partially and temporarily by daily administration of cortisone. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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