Exercise Ventilatory Inefficiency in Post-COVID-19 Syndrome: Insights from a Prospective Evaluation
| Autor: | David Andaluz-Ojeda, Williams Hinojosa, Sofía Jaurrieta-Largo, Álvaro Aparisi, Carolina Iglesias-Echeverría, Aitor Uribarri, J. Alberto San Román, Rosa Sedano-Gutiérrez, Javier Tobar, Mario García-Gómez, Blanca de Vega-Sánchez, Manuel Carrasco-Moraleja, Cristina Ybarra-Falcón, Carlos Baladrón, Marta Marcos-Mangas, Laura Fernández-Prieto, Ivan Cusacovich, Raquel Ladrón, Dolores Calvo, Amada Recio-Platero, Esther Sanz-Patiño, Pablo Catalá, Ignacio J. Amat-Santos, Carlos Disdier-Vicente |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Systemic disease
medicine.medical_specialty post-COVID-19 syndrome Medicina Enfermedades infecciosas 030204 cardiovascular system & hematology six-minute walking test Asymptomatic Article Pulmonary function testing 03 medical and health sciences 0302 clinical medicine pulmonary function test Quality of life Internal medicine medicine cardiopulmonary exercise testing 030212 general & internal medicine Hyperventilation syndrome Lung business.industry ventilatory inefficiency General Medicine dyspnea medicine.disease medicine.anatomical_structure Breathing Cardiology Medicine medicine.symptom Transthoracic echocardiogram business |
| Zdroj: | Journal of Clinical Medicine Volume 10 Issue 12 Journal of Clinical Medicine, Vol 10, Iss 2591, p 2591 (2021) |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm10122591 |
| Popis: | Introduction: Coronavirus disease 2019 (COVID-19) is a systemic disease characterized by a disproportionate inflammatory response in the acute phase. This study sought to identify clinical sequelae and their potential mechanism. Methods: We conducted a prospective single-center study (NCT04689490) of previously hospitalized COVID-19 patients with and without dyspnea during mid-term follow-up. An outpatient group was also evaluated. They underwent serial testing with a cardiopulmonary exercise test (CPET), transthoracic echocardiogram, pulmonary lung test, six-minute walking test, serum biomarker analysis, and quality of life questionaries. Results: Patients with dyspnea (n = 41, 58.6%), compared with asymptomatic patients (n = 29, 41.4%), had a higher proportion of females (73.2 vs. 51.7% p = 0.065) with comparable age and prevalence of cardiovascular risk factors. There were no significant differences in the transthoracic echocardiogram and pulmonary function test. Patients who complained of persistent dyspnea had a significant decline in predicted peak VO2 consumption (77.8 (64–92.5) vs. 99 (88–105) p < 0.00 0.001), total distance in the six-minute walking test (535 (467–600) vs. 611 (550–650) meters p = 0.001), and quality of life (KCCQ-23 60.1 ± 18.6 vs. 82.8 ± 11.3 0.001). Additionally, abnormalities in CPET were suggestive of an impaired ventilatory efficiency (VE/VCO2 slope 32 (28.1–37.4) vs. 29.4 (26.9–31.4) p = 0.022) and high PETCO2 (34.5 (32–39) vs. 38 (36–40) p = 0.025). Interpretation: In this study, > 50% of COVID-19 survivors present a symptomatic functional impairment irrespective of age or prior hospitalization. Our findings suggest a potential ventilation/perfusion mismatch or hyperventilation syndrome. |
| Databáze: | OpenAIRE |
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