NHC-Mediated Synthesis of Tricyclic Spirocarbocycles via an Intramolecular Stetter Reaction of Cyclic Enal-Enones
| Autor: | Day-Shin Hsu, Suz-Ping Liang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Organic Chemistry Stetter reaction chemistry.chemical_element 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences Ring size chemistry.chemical_compound chemistry Intramolecular force Carbene Carbon Tricyclic |
| Zdroj: | The Journal of organic chemistry. 85(2) |
| ISSN: | 1520-6904 |
| Popis: | A general and efficient method for the synthesis of tricyclic spirocarbocycles is described. Various cyclic enal-enones were reacted with an N-heterocyclic carbene, and an intramolecular Stetter reaction proceeded smoothly to give various tricyclic spiro-1,4-diketones in 31–72% yields. The ring size of the spiro compounds can be easily controlled using different cyclic enals and enones or by altering the length of the carbon tether. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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