Chitosan derivatives-based films as pH-sensitive drug delivery systems with enhanced antioxidant and antibacterial properties
| Autor: | Inmaculada Aranaz, Hana Maalej, Niuris Acosta, Angeles Heras, Sawsan Affes, Moncef Nasri |
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| Rok vydání: | 2021 |
| Předmět: |
Antioxidant
medicine.medical_treatment 02 engineering and technology Biochemistry Antioxidants Chitosan 03 medical and health sciences chemistry.chemical_compound Structural Biology Ciprofloxacin Tensile Strength Ultimate tensile strength medicine Molecular Biology Edible Films 030304 developmental biology 0303 health sciences Drug Carriers Water resistance Bacteria Chemistry General Medicine Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Anti-Bacterial Agents carbohydrates (lipids) Drug Liberation Cross-Linking Reagents Glutaral Drug delivery lipids (amino acids peptides and proteins) Glutaraldehyde Swelling medicine.symptom Elongation 0210 nano-technology Hydrophobic and Hydrophilic Interactions Nuclear chemistry |
| Zdroj: | International journal of biological macromolecules. 182 |
| ISSN: | 1879-0003 |
| Popis: | The purpose of this study was to develop and characterize chitosan (Ch)-based films incorporated with varying molecular weight (Mw) and acetylation degree (AD) chitosan-depolymerization-products (CDP), to be applied as drug delivery materials. As compared to Ch-film, optical and antioxidant potentials of Ch/CDP-based films were improved, particularly using low Mw and AD-CDP. Whereas, films water resistance, mechanical and antibacterial properties increased as CDP-Mw increased and AD decreased. For the thermal and swelling behaviors, better values were obtained using higher Mw and AD-CDP. Further, to assess their in vitro ciprofloxacin (CFX)-release behavior, loaded-CFX Ch/CDP-based films, crosslinked using glutaraldehyde, were prepared. Expect of elongation at break, crosslinked CFX-loaded films showed increased optical, water resistance, tensile strength and thermal properties, as compared to unloaded films. The CFX-release profiles indicated that a slower and sustained release was observed, particularly when using lower Mw and AD-CDP, and mainly for the crosslinked films during 48 h. These films can release CFX for up to 54% in 6 and 24 h, at pH 1.2 and 7.4, respectively. Through this study, novel biodegradable, swellable and pH-sensitive crosslinked Ch/CDP-based films may be considered as suitable and promising drug delivery systems. |
| Databáze: | OpenAIRE |
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