Prevalence of breast and ovarian cancer subtypes in Hispanic populations from Puerto Rico

Autor: Ariel Rodriguez-Velazquez, Adalberto Mendoza, Rosa Velez, Claudia B. Colon-Echevarria, Guillermo N. Armaiz-Pena, Jean Carlo Lafontaine, Ingrid Ramirez, Rocio Lamboy-Caraballo, Patricia Casbas-Hernandez
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Cancer Research
Pathological staging
Hispanics
0302 clinical medicine
Breast cancer
Epidemiology
Prevalence
Medicine
030212 general & internal medicine
10. No inequality
Ovarian Neoplasms
education.field_of_study
Incidence (epidemiology)
Hispanic or Latino
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Immunohistochemistry
3. Good health
Serous fluid
Oncology
Population Surveillance
030220 oncology & carcinogenesis
Cohort
Female
Research Article
Adult
medicine.medical_specialty
Population
Breast Neoplasms
lcsh:RC254-282
03 medical and health sciences
Ovarian cancer
Biomarkers
Tumor
Genetics
Humans
Latinos
Healthcare Disparities
education
Aged
Neoplasm Staging
Analysis of Variance
business.industry
Puerto Rico
medicine.disease
Neoplasm Grading
Health disparities
business
Demography
Zdroj: BMC Cancer, Vol 18, Iss 1, Pp 1-11 (2018)
BMC Cancer
ISSN: 1471-2407
DOI: 10.1186/s12885-018-5077-z
Popis: Background Previous epidemiological studies aimed at describing characteristics of breast (BC) and ovarian cancer (OC) patients tend to examine Hispanic populations using a mix of individuals that come from ethnically different Hispanic backgrounds. Since most USA cancer statistics do not include cancer data from Puerto Rico (PR), there is a lack of historical and descriptive data analysis for Hispanic women in the island that suffer from these diseases. Therefore, the aim of our study is to provide a comprehensive clinicopathological characterization of BC and OC cases in PR. Methods Our study consisted of a longitudinal retrospective review of archived pathology reports at Southern Pathology Services (SPS), which mostly serves southwestern PR, from years 2000–2015. After filtering SPS records with pre-established criteria, tumor samples from 3451 BC and 170 OC cases were used for descriptive statistics and analysis using R program. Results In our cohort, the mean age of diagnosis for BC was 60.5 years and 60.3 years for OC. Available data for subtype characterization from BC cases, exhibited an expected subtype distribution that remained stable over time (Luminal A = 68.8%, Luminal B = 9.7%, HER-2 = 6.1% and Triple negative = 15.4%). Additionally, tumor grades distribution varied within different BC subtypes in which the majority of Luminal A tumors were G2 and most Triple negative tumors were G3. For OC cases, available subtype and tumor grade information identified serous histology in 64.71% of all cases and G3 as being the most prevalent tumor grade. Pathology reports revealed that 39.42% of all OC cases were described as late stage, while 50.5% as early stage (by pathological staging). Conclusion Our data suggests that OC and BC subtypes distribution in Hispanic populations from PR are in-line with national averages. In a significant number of BC cases, subtype could not be determined due to study limitations, health insurance coverage, or other reasons described here and may constitute a health disparity. Altogether, and despite these gaps, this study represents one of the most complete reviews of BC and OC in PR and provides an opportunity to further study this population separate from other US Hispanic populations. Electronic supplementary material The online version of this article (10.1186/s12885-018-5077-z) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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