Effects of hyperhomocysteinemia during the gestational period on ossification in rat embryo
| Autor: | Gholamhossein Ranjbar Omrani, Zabih Allah Azizi, Mohammad Reza Namavar, Layla Omrani, Ali Zamani, Ladan Ranjbar Omrani, Mohammad Hossein Dabaghmanesh, Alireza Mohammadi |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Hyperhomocysteinemia Histology Homocysteine Physiology Offspring Endocrinology Diabetes and Metabolism Gestational Age Rats Sprague-Dawley chemistry.chemical_compound Osteogenesis Pregnancy Internal medicine medicine Animals Tibia Growth Plate Fetus Microscopy business.industry Gestational age Anatomy medicine.disease Spine Rats Osteopenia Pregnancy Complications Bone Diseases Metabolic Radius Endocrinology chemistry Animals Newborn Female business |
| Zdroj: | Bone. 46(5) |
| ISSN: | 1873-2763 |
| Popis: | Severe hyperhomocysteinemia, as seen in classic homocystinuria, is associated with several skeletal malformations and osteopenia. Moreover, hyperhomocysteinemia during pregnancy has been associated with multiple developmental defects in the fetus. This study was undertaken to determine whether offspring of hyperhomocysteinemic mothers have demonstrable changes in bone volume and the epiphyseal growth plate. Ten adult female Sprague-Dawley rats were randomly assigned to the control or experimental group. The experimental group received 100 mg/kg/day of homocysteine in their drinking water for 3 weeks before mating and for the total duration of pregnancy. In each group, three pups per mother were randomly selected. The histomorphometric properties of tibial, radial and vertebral growth plates of newborn rats and the volume fraction of bone were compared between groups. The plasma homocysteine concentration at the end of study was significantly higher in dams in the experimental group (16.42+/-1.5 vs. 4.7+/-1.7 mumol/L, P |
| Databáze: | OpenAIRE |
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