Antiviral and Antioxidant Properties of Echinochrome A

Autor: Galina N. Leonova, Natalia V. Krylova, Sergey A. Fedoreyev, Natalia P. Mishchenko, Linna K Ebralidze, Evgeny A Pislyagin, O.A. Svitich, Elena A Vasileva, Vyacheslav F Lavrov, Olga V. Iunikhina
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Antioxidant
viruses
medicine.medical_treatment
alpha-Tocopherol
Pharmaceutical Science
antioxidant activity
Ascorbic Acid
Herpesvirus 1
Human
medicine.disease_cause
01 natural sciences
Antiviral Agents
Virus
Article
Antioxidants
Encephalitis Viruses
Tick-Borne
03 medical and health sciences
Drug Discovery
Chlorocebus aethiops
medicine
Animals
Echinochrome A
Pharmacology
Toxicology and Pharmaceutics (miscellaneous)
Vero Cells
lcsh:QH301-705.5
Biological Products
echinochrome A
010405 organic chemistry
Chemistry
Ascorbic acid
composition of antioxidants
In vitro
0104 chemical sciences
Drug Combinations
030104 developmental biology
Herpes simplex virus
Biochemistry
lcsh:Biology (General)
Sea Urchins
antiviral activity
Lipid Peroxidation
Reactive Oxygen Species
Naphthoquinones
Zdroj: Marine Drugs, Vol 16, Iss 12, p 509 (2018)
Marine Drugs
Volume 16
Issue 12
ISSN: 1660-3397
Popis: The aim of this study was to examine the in vitro antioxidant and antiviral activities of echinochrome A and echinochrome-based antioxidant composition against tick-borne encephalitis virus (TBEV) and herpes simplex virus type 1 (HSV-1). The antioxidant composition, which is a mixture of echinochrome A, ascorbic acid, and &alpha
tocopherol (5:5:1), showed higher antioxidant and antiviral effects than echinochrome A. We suppose that echinochrome A and its composition can both directly affect virus particles and indirectly enhance antioxidant defense mechanisms in the hosting cell. The obtained results allow considering the echinochrome A and the composition of antioxidants on its basis as the promising agents with the both antioxidant and antiviral activities.
Databáze: OpenAIRE
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