Monitoring Indoor Exposure to Organophosphate Flame Retardants: Hand Wipes and House Dust
Autor: | Stavros Garantziotis, Linda S. Birnbaum, Kate Hoffman, Heather M. Stapleton |
---|---|
Rok vydání: | 2015 |
Předmět: |
Adult
Male Health Toxicology and Mutagenesis Polybrominated Biphenyls Air pollution medicine.disease_cause chemistry.chemical_compound Organophosphorus Compounds Environmental monitoring North Carolina medicine Humans News | Science Selections Aged Flame Retardants Extramural Research Diphenyl ether Organophosphate technology industry and agriculture Public Health Environmental and Occupational Health Dust Middle Aged Organophosphates Polybrominated Diphenyl Ethers (PBDEs) 3. Good health chemistry Air Pollution Indoor Environmental chemistry Women's Health Female Men's Health Personal Care Products Environmental Monitoring |
Zdroj: | Environmental Health Perspectives |
ISSN: | 1552-9924 0091-6765 |
Popis: | Background: Organophosphate flame retardants (PFRs) are becoming popular replacements for the phased-out polybrominated diphenyl ether (PBDE) mixtures, and they are now commonly detected in indoor environments. However, little is known about human exposure to PFRs because they cannot be easily measured in blood or serum. Objectives: To investigate relationships between the home environment and internal exposure, we assessed associations between two PFRs, tris(1,3-dichloropropyl) phosphate (TDCIPP) and triphenyl phosphate (TPHP), in paired hand wipe and dust samples and concentrations of their metabolites in urine samples (n = 53). We also assessed short-term variation in urinary metabolite concentrations (n = 11 participants; n = 49 samples). Methods: Adult volunteers in North Carolina, USA, completed questionnaires and provided urine, hand wipe, and household dust samples. PFRs and PBDEs were measured in hand wipes and dust, and bis(1,3-dichloropropyl) phosphate (BDCIPP) and diphenyl phosphate (DPHP), metabolites of TDCIPP and TPHP, were measured in urine. Results: TDCIPP and TPHP were detected frequently in hand wipes and dust (> 86.8%), with geometric mean concentrations exceeding those of PBDEs. Unlike PBDEs, dust TDCIPP and TPHP levels were not associated with hand wipes. However, hand wipe levels were associated with urinary metabolites. Participants with the highest hand wipe TPHP mass, for instance, had DPHP levels 2.42 times those of participants with the lowest levels (95% CI: 1.23, 4.77). Women had higher levels of DPHP, but not BDCIPP. BDCIPP and DPHP concentrations were moderately to strongly reliable over 5 consecutive days (intraclass correlation coefficients of 0.81 and 0.51, respectively). Conclusions: PFR exposures are widespread, and hand-to-mouth contact or dermal absorption may be important pathways of exposure. Citation: Hoffman K, Garantziotis S, Birnbaum LS, Stapleton HM. 2015. Monitoring indoor exposure to organophosphate flame retardants: hand wipes and house dust. Environ Health Perspect 123:160–165; http://dx.doi.org/10.1289/ehp.1408669 |
Databáze: | OpenAIRE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |