Pretreatment lymphocyte-monocyte ratio as a potential prognostic factor in a cohort of patients with upper tract urothelial carcinoma
| Autor: | Orietta Dalpiaz, N Sobolev, Karl Pummer, Georg C. Hutterer, Tatjana Stojakovic, Richard Zigeuner, Sebastian Mannweiler, Georg C. Ehrlich, Martin Pichler, T. Gutschi |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Prognostic factor medicine.medical_specialty Urologic Neoplasms Multivariate analysis Time Factors Lymphocyte Urology Kaplan-Meier Estimate Monocytes Pathology and Forensic Medicine Predictive Value of Tests Risk Factors Medicine Humans Lymphocyte Count Lymphocytes Radical surgery Upper urinary tract Aged Neoplasm Staging Proportional Hazards Models Retrospective Studies Aged 80 and over Chi-Square Distribution business.industry Proportional hazards model Monocyte Carcinoma Age Factors General Medicine Middle Aged Surgery medicine.anatomical_structure Treatment Outcome ROC Curve Area Under Curve Austria Cohort Multivariate Analysis Female Urothelium business |
| Zdroj: | Journal of clinical pathology. 68(5) |
| ISSN: | 1472-4146 |
| Popis: | To investigate the potential prognostic impact of the lymphocyte-monocyte ratio (LMR) in a large European cohort of patients with localised upper urinary tract urothelial carcinoma (UTUC). The LMR as an indicator of systemic inflammatory response has been shown to represent a potential prognostic factor in various types of human cancers. Up to date, the prognostic significance of the LMR in UTUC has not been evaluated.Clinico-pathological data from 182 non-metastatic patients with UTUC, operated between 1990 and 2012 at a single tertiary academic centre, were evaluated retrospectively. Pretreatment LMR was assessed 1 day before surgery. Patients were categorised using an LMR cut-off value of 2.0 according to a calculation by receiver-operating curve analysis. Patients' overall survival (OS) was assessed using the Kaplan-Meier method. To evaluate the independent prognostic significance of the LMR, a multivariate proportional Cox regression model was applied for OS.In multivariate analyses, age on the date of surgery (65 vs ≥65 years, HR=2.10, 95% CI 1.22 to 3.64), pathological T-stage (pT1 vs pT2-4, HR=2.15, 95% CI 1.26 to 3.67), as well as the LMR (2 vs ≥2, HR=0.56, 95% CI 0.35 to 0.92) were independent predictors of OS of patients with UTUC.In the cohort studied, patients with an elevated (≥2) preoperative LMR had a subsequently longer OS after radical surgery for UTUC, compared with those with a low (2) preoperative LMR. Thus, we believe this parameter might be considered an additional prognostic factor in UTUC in the future. |
| Databáze: | OpenAIRE |
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