Development of an intein-inspired amide cleavage chemical device
| Autor: | Tsubasa Inokuma, Hao Ding, Ko Morishita, Akira Shigenaga, Akira Otaka, Chiaki Komiya, Keisuke Aihara |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Models
Molecular Geminal 010405 organic chemistry Stereochemistry Organic Chemistry 010402 general chemistry Cleavage (embryo) Photochemical Processes 01 natural sciences Amides 0104 chemical sciences Inteins chemistry.chemical_compound chemistry Protein splicing Amide Organic chemistry Peptide bond Protein Splicing Amine gas treating Asparagine Intein |
| Zdroj: | The Journal of Organic Chemistry. 81(2):699-707 |
| ISSN: | 0022-3263 |
| Popis: | A photo-responsive amide cleavage device was developed based on the asparagine imidation-mediated cleavage of peptide bonds during intein-mediated protein splicing. The chemical environment of the protein splicing process was mimicked by the incorporation of geminal dimethyl groups and a secondary amine unit in asparagine scaffold. Furthermore, the resulting photo-responsive device could induce the photo-triggered cleavage of an amide bond by the protection of the secondary amine unit with an o-nitrobenzyloxycarbonyl group. |
| Databáze: | OpenAIRE |
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