Deregulated homeobox gene expression in cancer: cause or consequence?
Autor: | Cory Abate-Shen |
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Rok vydání: | 2002 |
Předmět: |
Models
Molecular Genetics Applied Mathematics General Mathematics DLX3 Genes Homeobox Homeobox A1 Gene Expression Regulation Developmental Biology HNF1B Models Biological Protein Structure Tertiary Homeobox protein Nkx-2.5 HNF1A NKX2-3 Gene Expression Regulation Neoplastic Protein Transport Neoplasms Cancer research Animals Humans Homeobox Drosophila CDX2 |
Zdroj: | Nature Reviews Cancer. 2:777-785 |
ISSN: | 1474-1768 1474-175X |
Popis: | Homeobox genes comprise a large and essential family of developmental regulators that are vital for all aspects of growth and differentiation. Although many studies have reported their deregulated expression in cancer, few studies have established direct functional roles for homeobox genes in carcinogenesis. Nonetheless, most cases of deregulated homeobox gene expression in cancer conform to a simple rule: those that are normally expressed in undifferentiated cells are upregulated in cancer, whereas those that are normally expressed in differentiated tissues are downregulated in cancer. |
Databáze: | OpenAIRE |
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