CORRELATIONS OF LOW MOLECULAR WEIGHT PHENOTYPE OF APOPROTEIN(A) AND SERUM LEVEL OF LIPOPROTEIN(A) WITH MULTIFOCAL ATHEROSCLEROSIS IN PATIENTS WITH CORONARY HEART DISEASE
| Autor: | Olga I. Afanasieva, M.I. Afanasieva, Marat V. Ezhov, M. S. Safarova, J. V. Berestetskaya, S. N. Pokrovsky |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Systemic disease
medicine.medical_specialty RM1-950 apoprotein(a) Internal medicine Diabetes mellitus Hyperlipidemia medicine Diseases of the circulatory (Cardiovascular) system Pharmacology (medical) coronary heart disease apo(a) phenotype biology medicine.diagnostic_test business.industry Lipoprotein(a) medicine.disease Phenotype Peripheral Endocrinology RC666-701 biology.protein Therapeutics. Pharmacology atherosclerosis Cardiology and Cardiovascular Medicine Lipid profile business Lipoprotein |
| Zdroj: | Racionalʹnaâ Farmakoterapiâ v Kardiologii, Vol 6, Iss 4, Pp 474-480 (2016) |
| ISSN: | 2225-3653 1819-6446 |
| Popis: | Background. Atherosclerosis is a systemic disease. That is why the damage is not restricted by one vascular area in 18-50% of patients. High serum level of lipoprotein(a) [Lp(a)] is an independent risk factor for coronary, carotid and peripheral atherosclerosis. However the correlation of apoprotein(a) [apo(a)] polymorphism with the multifocal atherosclerosis in coronary heart disease (CHD) is not sufficiently studied. Aim. To study the correlation of apo(a) phenotype with the multifocal atherosclerosis in CHD patients. Material and Methods. 220 patients aged 32- 76 y.o. with the proven coronary and carotid atherosclerosis were split into two groups depending on the presence (n=22) or absence (n=198) of peripheral atherosclerosis. Evaluation of lipid profile, Lp(a) and determination of apo(a) isoforms by SDS electrophoresis in polyacrylamide gel and immunoblotting was performed in all patients. Results. Both groups of patients were comparable by age, sex, classical cardiovascular risk factors, including frequency of hyperlipidemia and diabetes mellitus, lipid profile. The Lp(a) serum level ≥30 mg/dL and low molecular weight (LMW) apo(a) phenotype were found more often in patients with multifocal than coronary and carotid atherosclerosis: 55 and 45% (р=0.372); 73 and 44% (p |
| Databáze: | OpenAIRE |
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