Plasma Lipid Profiling Shows Similar Associations with Prediabetes and Type 2 Diabetes
Autor: | Adam Kowalczyk, Michael C. Mahaney, Jacquelyn M. Weir, Jonathan E. Shaw, Melissa A. Greeve, Christopher K. Barlow, Peter J. Meikle, Gemma L MacIntosh, Dianna J. Magliano, Joanne E. Curran, Izhak Haviv, Anthony G. Comuzzie, Gerard Wong, Laura Almasy, Narelle Grantham, Jeremy B M Jowett, Paul Zimmet, John Blangero |
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Rok vydání: | 2013 |
Předmět: |
Blood Glucose
Male medicine.medical_specialty lcsh:Medicine Type 2 diabetes 030204 cardiovascular system & hematology Biology Cohort Studies Prediabetic State Impaired glucose tolerance 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus medicine Humans Prediabetes lcsh:Science Aged 030304 developmental biology 0303 health sciences Multidisciplinary lcsh:R Type 2 Diabetes Mellitus Lipid metabolism Middle Aged Impaired fasting glucose medicine.disease Lipids 3. Good health Endocrinology Diabetes Mellitus Type 2 Female lcsh:Q lipids (amino acids peptides and proteins) Dyslipidemia Research Article |
Zdroj: | PLoS ONE, Vol 8, Iss 9, p e74341 (2013) PLoS ONE |
ISSN: | 1932-6203 |
Popis: | The relationship between lipid metabolism with prediabetes (impaired fasting glucose and impaired glucose tolerance) and type 2 diabetes mellitus is poorly defined. We hypothesized that a lipidomic analysis of plasma lipids might improve the understanding of this relationship. We performed lipidomic analysis measuring 259 individual lipid species, including sphingolipids, phospholipids, glycerolipids and cholesterol esters, on fasting plasma from 117 type 2 diabetes, 64 prediabetes and 170 normal glucose tolerant participants in the Australian Diabetes, Obesity and Lifestyle Study (AusDiab) then validated our findings on 1076 individuals from the San Antonio Family Heart Study (SAFHS). Logistic regression analysis of identified associations with type 2 diabetes (135 lipids) and prediabetes (134 lipids), after adjusting for multiple covariates. In addition to the expected associations with diacylglycerol, triacylglycerol and cholesterol esters, type 2 diabetes and prediabetes were positively associated with ceramide, and its precursor dihydroceramide, along with phosphatidylethanolamine, phosphatidylglycerol and phosphatidylinositol. Significant negative associations were observed with the ether-linked phospholipids alkylphosphatidylcholine and alkenylphosphatidylcholine. Most of the significant associations in the AusDiab cohort (90%) were subsequently validated in the SAFHS cohort. The aberration of the plasma lipidome associated with type 2 diabetes is clearly present in prediabetes, prior to the onset of type 2 diabetes. Lipid classes and species associated with type 2 diabetes provide support for a number of existing paradigms of dyslipidemia and suggest new avenues of investigation. |
Databáze: | OpenAIRE |
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