Cardiovascular calcification: current controversies and novel concepts
| Autor: | Elena Aikawa, Jessica L. Ruiz, Joshua D. Hutcheson |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Aortic valve
Pathology medicine.medical_specialty Future studies Cell Culture Techniques Cell Communication medicine.disease_cause Pathology and Forensic Medicine Cardiovascular calcification Medicine Animals Humans Vascular Calcification Vascular calcification Cells Cultured business.industry Mechanism (biology) Calcinosis General Medicine Aortic Valve Stenosis Arteries medicine.disease Atherosclerosis Vulnerable plaque Plaque Atherosclerotic Biomechanical Phenomena medicine.anatomical_structure Phenotype Aortic valve stenosis Aortic Valve Cardiology and Cardiovascular Medicine business Calcification |
| Zdroj: | Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. 24(4) |
| ISSN: | 1879-1336 |
| Popis: | Cardiovascular calcification is a commonly observed but incompletely understood mechanism of increased atherosclerotic plaque instability and accelerated aortic valve stenosis. Traditional histological staining and imaging techniques are nonspecific for the type of mineral present in calcified tissues, information that is critical for proper validation of in vitro and in vivo models. This review highlights current gaps in our understanding of the biophysical implications and the cellular mechanisms of valvular and vascular calcification and how they may differ between the two tissue types. We also address the hindrances of current cell culture systems, discussing novel platforms and important considerations for future studies of cardiovascular calcification. |
| Databáze: | OpenAIRE |
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