Precision of attenuation coefficient measurements by optical coherence tomography
| Autor: | Linda B. Neubrand, Ton G. van Leeuwen, Dirk J. Faber |
|---|---|
| Přispěvatelé: | Biomedical Engineering and Physics, Graduate School, ACS - Atherosclerosis & ischemic syndromes |
| Rok vydání: | 2022 |
| Předmět: |
Likelihood Functions
optical coherence tomography Biomedical Engineering OCT signal simulation maximum likelihood estimation Signal-To-Noise Ratio Atomic and Molecular Physics and Optics Electronic Optical and Magnetic Materials Biomaterials Cramér-Rao lower bound attenuation coefficient curve-fitting Least-Squares Analysis Fisher-information matrix Tomography Optical Coherence |
| Zdroj: | Journal of biomedical optics, 27(8):085001. SPIE |
| ISSN: | 1560-2281 1083-3668 |
| Popis: | SIGNIFICANCE: Optical coherence tomography (OCT) is an interferometric imaging modality, which provides tomographic information on the microscopic scale. Furthermore, OCT signal analysis facilitates quantification of tissue optical properties (e.g., the attenuation coefficient), which provides information regarding the structure and organization of tissue. However, a rigorous and standardized measure of the precision of the OCT-derived optical properties, to date, is missing. AIM: We present a robust theoretical framework, which provides the Cramér -Rao lower bound σμOCT for the precision of OCT-derived optical attenuation coefficients. APPROACH: Using a maximum likelihood approach and Fisher information, we derive an analytical solution for σμOCT when the position and depth of focus are known. We validate this solution, using simulated OCT signals, for which attenuation coefficients are extracted using a least-squares fitting procedure. RESULTS: Our analytical solution is in perfect agreement with simulated data without shot noise. When shot noise is present, we show that the analytical solution still holds for signal-to-noise ratios (SNRs) in the fitting window being above 20 dB. For other cases (SNR |
| Databáze: | OpenAIRE |
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