Effects of calcineurin inhibitors on sodium excretion in recipients of allogeneic hematopoietic stem cell transplantation

Autor: Shinichiro Okamoto, Yusuke Yamane, Risa Hashida, Jun Kato, Sayako Yuda, Daiki Karigane, Yuya Koda, Ryohei Abe, Junichi Hirahashi, Takehiko Mori, Masuho Saburi, Sumiko Kohashi, Takaaki Toyama, Tomonori Nakazato, Masao Ogata, Masatoshi Sakurai, Taku Kikuchi
Rok vydání: 2017
Předmět:
Zdroj: International Journal of Hematology. 106:431-435
ISSN: 1865-3774
0925-5710
DOI: 10.1007/s12185-017-2253-x
Popis: Calcineurin inhibitors (CIs) such as cyclosporine A (CSA) and tacrolimus often cause renal dysfunction, resulting in increased serum creatinine, hyperkalemia, and hyperuricemia. However, the effects of CIs on sodium excretion have not been fully elucidated. We retrospectively evaluated the effects of CI administration on sodium excretion in recipients of allogeneic hematopoietic stem cell transplantation (HSCT). Fifty consecutive recipients each of allogeneic HSCT receiving either CSA or tacrolimus (100 patients in total) with available data for weekly fractional excretion of sodium (FENa) for a 4-week period after transplantation were enrolled in this retrospective analysis. No significant differences in patient characteristics were observed between CSA and tacrolimus groups except for the type of donor. FENa was significantly higher at the 3rd (1.25 ± 0.80) and 4th weeks (1.53 ± 1.06) after transplantation as compared with that at the 1st week (0.93 ± 0.51; P < 0.01, P < 0.001, respectively) in the tacrolimus group, but not at any time point in the CSA group. In addition, FENa was significantly higher in the tacrolimus group than the CSA group at the 4th week (1.53 ± 1.06 vs. 1.13 ± 0.80; P < 0.05). These results suggest that tacrolimus increases sodium excretion after allogeneic HSCT, and that this effect is minimal with CSA.
Databáze: OpenAIRE
Externí odkaz: