Analysis of Driver Mutations in Female Non-Smoker Asian Patients with Pulmonary Adenocarcinoma
| Autor: | Xiaoxia Chen, Peng Kuang, Jie Zhang, Bing Li, Liang Tang, Jiayu Li, Yongshen Wang, Lu Liu, Qiong Hu, Caicun Zhou, Chunxia Su, V. KimCurran, Limou Zheng, Shengxiang Ren |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Proto-Oncogene Proteins B-raf Oncology medicine.medical_specialty Lung Neoplasms Oncogene Proteins Fusion medicine.medical_treatment DNA Mutational Analysis Population Biophysics Adenocarcinoma of Lung Adenocarcinoma Biology medicine.disease_cause Biochemistry Targeted therapy Proto-Oncogene Proteins p21(ras) Phosphatidylinositol 3-Kinases T790M Gefitinib Asian People Proto-Oncogene Proteins Internal medicine medicine Humans Missense mutation Lung cancer education Aged Neoplasm Staging Mutation education.field_of_study Smoking Exons Cell Biology General Medicine Middle Aged medicine.disease respiratory tract diseases ErbB Receptors ras Proteins Female KRAS medicine.drug |
| Zdroj: | Cell Biochemistry and Biophysics. 64:155-160 |
| ISSN: | 1559-0283 1085-9195 |
| DOI: | 10.1007/s12013-012-9384-8 |
| Popis: | Previous studies have revealed that EGFR mutation and/or EML4-ALK gene fusion rate was higher in the non-smoker Asian females with pulmonary adenocarcinoma. The aim of this study is to determine the distribution of known oncogenic driver mutations in the female non-smoker Asian patients with pulmonary adenocarcinoma. 104 consecutively resected lung adenocarcinomas from 396 non-smoker females (less than 100 cigarettes in a lifetime) at a single institution (Tongji University, Shanghai, China) were analyzed for mutations in EGFR, EML4-ALK, KRAS, HER2, BRAF, and PIK3CA. 73 (70.2 %) tumors harbored EGFR mutations; among these, 28 were deletions in exon 19, 44 were L858R missense changes, and eight were T790M mutations. 10 (9.6 %) harbored EML4-ALK fusions, two harbored KRAS mutations, two harbored BRAF mutations, and two harbored PI3K mutations. A majority of the mutations were mutually exclusive, except two with EGFR mutation and BRAF mutation, one with EML4-ALK fusions and PI3K mutation. Thus, 82.7 % (86 of 104; 95 % CI, 75.4-90.0 %) of lung adenocarcinomas from non-smoker females were found to harbor the well-known oncogenic mutations in five genes. Lung cancer in non-smoking Asian females is a distinct entity, with majority of this subgroup being developed by the oncogenic mutations. The prospective mutation examination in this population will be helpful for devising a targeted therapy for a majority of the patients. |
| Databáze: | OpenAIRE |
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