The Angiotensin II Type 1 (AT1) Receptor and Cardiac Hypertrophy
| Autor: | Fouad A. Zouein, Gaelle P Massoud, Raffaele Altara, George W. Booz |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Concentric hypertrophy Blood Pressure Cardiomegaly 030204 cardiovascular system & hematology Receptor Angiotensin Type 1 Muscle hypertrophy Mice 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Animals Receptor Pharmacology Pressure overload Angiotensin II receptor type 1 business.industry Angiotensin II medicine.disease 030104 developmental biology Endocrinology Blood pressure Heart failure Hypertension cardiovascular system Cardiology and Cardiovascular Medicine business hormones hormone substitutes and hormone antagonists circulatory and respiratory physiology |
| Zdroj: | Journal of Cardiovascular Pharmacology. |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/fjc.0000000000000999 |
| Popis: | An ongoing issue in cardiac pharmacology is whether angiotensin II has direct growth promoting effects on the heart via the angiotensin II type 1 (AT1) receptor. This question has relevance for whether angiotensin-converting enzyme inhibitors and AT1 receptor blockers offer additional benefit in preventing adverse cardiac remodeling in hypertension. In a recent study, 2 strains of mice were infused with angiotensin II. In both, AT1 receptors were deleted in the heart and conduit vessels, but in one, AT1 receptors were also deleted in resistance vessels. Angiotensin II caused hypertrophy and hypertension in the strain lacking AT1 receptors in the heart and conduit vessels, but not in the strain without AT1 receptors in resistance vessels. This finding supports the conclusion that blood pressure is more important in determining cardiac hypertrophy than direct AT1 activation by angiotensin II, when the two are rapidly and simultaneously introduced. Surprisingly, mice with no cardiac AT1 receptor expression developed ventricular dilation and eccentric hypertrophy with pressure overload, in contrast to wild type mice that exhibited concentric hypertrophy, suggesting that cardiac AT1 receptors protect against high blood pressure. This interpretation revives issues related to β-arrestin-biased signaling and mechanosensitivity of AT1 receptors. Synthetic nanobodies, which are based on the variable regions of camelid-derived heavy chain-only antibodies, could be applied to explore the therapeutic potential of exploiting different activation states of AT1 under stress conditions, such as hypertension and heart failure. At the very least, this experimental approach is likely to reveal new facets of AT1 receptor signaling in the heart. |
| Databáze: | OpenAIRE |
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