Increased functional connectivity between language and visually deprived areas in late and partial blindness
| Autor: | José-Alain Sahel, Avinoam B. Safran, Nicolae Sanda, Amir Amedi, Christophe Habas, Norman Sabbah, Saddek Mohand-Said, Colas N. Authié |
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| Přispěvatelé: | Institut de la Vision, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts (CHNO), Institute of Ophthalmology [London], University College of London [London] (UCL), Fondation Ophtalmologique Adolphe de Rothschild [Paris], Dpt of Clinical Neurosciences [Geneva], University of Geneva School of Medicine, Department of Medical Neurobiology [Jérusalem], The Hebrew University of Jerusalem (HUJ), The Edmond and Lily Safra Center for brain sciences [Jérusalem] (ELSC), The cognitive science program [Jérusalem], HAL-UPMC, Gestionnaire, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
genetic structures Blindness Brain mapping Language & vision 0302 clinical medicine Foveal Neural Pathways Tunnel vision Adult brain plasticity Language Visual Cortex Brain Mapping [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology Neuronal Plasticity 05 social sciences Middle Aged Retinitis pigmentosa medicine.anatomical_structure Neurology Cerebral reorganization Female [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] medicine.symptom Psychology Adult Cognitive Neuroscience 050105 experimental psychology 03 medical and health sciences Neuroplasticity medicine Humans 0501 psychology and cognitive sciences Sensory deprivation [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Resting-state fMRI Brain connectivity Resting state fMRI medicine.disease Broca Area eye diseases Visual cortex Critical periods Nerve Net Sensory Deprivation Visual Fields Neuroscience 030217 neurology & neurosurgery [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | NeuroImage NeuroImage, 2016, ⟨10.1016/j.neuroimage.2016.04.056⟩ NeuroImage, Elsevier, 2016, ⟨10.1016/j.neuroimage.2016.04.056⟩ |
| ISSN: | 1053-8119 1095-9572 |
| DOI: | 10.1016/j.neuroimage.2016.04.056⟩ |
| Popis: | International audience; In the congenitally blind, language processing involves visual areas. In the case of normal visual development however, it remains unclear whether later visual loss induces interactions between the language and visual areas. This study compared the resting-state functional connectivity (FC) of retinotopic and language areas in two unique groups of late visually deprived subjects: (1) blind individuals suffering from retinitis pigmentosa (RP), (2) RP subjects without a visual periphery but with preserved central “tunnel vision”, both of whom were contrasted with sighted controls. The results showed increased FC between Broca's area and the visually deprived areas in the peripheral V1 for individuals with tunnel vision, and both the peripheral and central V1 for blind individuals. These findings suggest that FC can develop in the adult brain between the visual and language systems in the completely and partially blind. These changes start in the deprived areas and increase in size (involving both foveal and peripheral V1) and strength (from negative to positive FC) as the disease and sensory deprivation progress. These observations support the claim that functional connectivity between remote systems that perform completely different tasks can change in the adult brain in cases of total and even partial visual deprivation. |
| Databáze: | OpenAIRE |
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